Purpose Methods to assess the authenticity and traceability of wines have been extensively studied as enhancers food quality, allowing producers obtain market recognition premium prices. Among analytical techniques, volatilome profile attained by gas chromatography coupled with mass spectrometry is acquiring more attention scientific community, together use chemometrics Design/methodology/appro...

Isopropyl has replaced ethyl alcohol in many such pharmaceutical preparations and cosmetics as mouth washes, dental solutions, and hair tonics. Although the physiology and toxicity of this material are fairly well known, a thorough knowledge of the metabolism involves a method for the separate determination of isopropyl alcohol and acetone, the chief product of its oxidation in the body. Many o...

A series of 2,6-disubstituted pyridine derivatives were prepared from 2,6-diacetylpyridine or 2,6dicarbonyl pyridine dichloride as starting materials. Reaction of 2,6-diacetylpyridine 1 with hydroxylamine hydrochloride or different aromatic aldehydes afforded the corresponding 2,6-diacetylpyridine dioxime and 2,6-bis-[β -(2-thienyl)acryloyl]pyridine derivatives 2 and 3, respectively. Additional...

Three simple sensitive and reproducible visible spectrophotometric methods (A, B, and C) for the determination of Naratriptan hydrochloride (NTP) in bulk samples and pharmaceutical formulations are described. Method A is based on the formation of colored co-ordination complex with cobalt thiocyanate (CTC). Method B is based on the formation of colored species with citric acid acetic anhydride (...

Preparation of an agarose derivative (MPE-agarose) containing a maleimido group which is attached to agarose via a cleavable phenyl ester linkage is described. MPE-agarose was shown to react with the thiol groups in glutathione, bovine serum albumin, bovine hemoglobin, and yeast and rabbit muscle glyceraldehyde 3-phosphate dehydrogenase. Treatment of the resulting agarose-linked compounds for 1...

The optimized coupling of N-protected (S)-proline and (2S,4R)-4-hydroxyproline derivatives with (Z)-4-aminopent-3-en-2-one provided the expected β-ketoenamides in good to excellent yields. subsequent intramolecular cyclizations afforded enantiopure pyridin-4-one pyrrolidin-2-yl substituents. nonaflates generated from these intermediates were precursors for typical palladium-catalyzed reactions....

Abstract The cleaning or removal of manganese stains on Cultural Heritage has not been much tested successful so far. aim this article was to assess a new green gel for Mn-rich black-blue different substrates. were characterized at optical and chemical level through colour-related data, microscope, FTIR, XRF XPS. Mn-stained granite found historical churches Vila Real (North Portugal) glass jars...

A series of novel 3-(substituted phenyl)-6,7-dimethoxy-3a,4-dihydro-3H-indeno[1,2-c]isoxazole analogues were synthesized by the reaction of 5,6-dimethoxy-2-[(E)-1-phenylmethylidene]-1-indanone with hydroxylamine hydrochloride. The title compounds were tested for their in vitro anti-HIV activity. Among the compounds, (4g) showed a promising anti-HIV activity in the in vitro testing against IIIB ...

Arylhydrazonomalononitriles 1a,b react with phenylhydrazine to yield amidrazones 2a,b that cyclize to give 2-aryl-5-phenylhydrazono-2,5-dihydro-[1,2,4]-triazine-6-carbonitriles 5a,b upon reaction with dimethylformamide dimethylacetal (DMFDMA). Refluxing 5a,b in glacial acetic acid resulted in the formation of the pyrazolo-1,2,4-triazines 6a,b. Compounds 6a,b were also formed upon treatment of 3...

New mechanochemical pathways for the transformation of six N-heterocyclic carbonyl compounds into oximes using hydroxylamine hydrochloride were explored. Reactions were performed first without any base since the heterocyclic moieties (imidazole, benzimidazole, pyridine and quinuclidine) have an intrinsic basic nitrogen atom. This green, solvent free method was suitable for all compounds (up to ...