Many aldehydes are important components of natural flavours. They are used in food, cosmetic, and biomedical industries in large amounts. Plant cells or microorganisms carry out their production by biotransformation, which is one of the biotechnological methods that allow them to be defined as 'natural'. Cell cultures of Silybum marianum and Peganum harmala have been studied with a view to in...

A new method for the simultaneous determination of hemoglobin adducts from aromatic amines and tobacco-specific nitrosamines (TSNA) is described. After mild base-catalysed hydrolysis releasing aromatic amines and the TSNA adduct 4-hydroxy-1-(3-pyridyl)-1butanone (HPB), the extraction, cleanup, and concentration are performed by a one-step procedure using C 1 8 cartridges. Determination in the p...

A direct and asymmetric aldol reaction of N-acyl thiazinanethiones with aromatic aldehydes catalyzed by chiral nickel(II) complexes is reported. The gives the corresponding O-TIPS-protected anti-aldol adducts in high yields remarkable stereocontrol atom economy. Furthermore, straightforward removal achiral scaffold provides enantiomerically pure intermediates synthetic interest, which involve p...

INTRODUCTION 3-Methylcholanthrene and eight of its metabolites were tested for tumonigenic activity in two tumor models. In the tumonigenicity study on mouse skin, a single topical application of 3 to 30 nmol of compound was followed 7 days later by twice weekly applications of the tumor promotor i 2-0-tetra decanoylphorbol-i 3-acetate for 30 weeks. Comparisons of the percentage of mice with tu...

INTRODUCTION 3-Methylcholanthrene and eight of its metabolites were tested for tumonigenic activity in two tumor models. In the tumonigenicity study on mouse skin, a single topical application of 3 to 30 nmol of compound was followed 7 days later by twice weekly applications of the tumor promotor i 2-0-tetra decanoylphorbol-i 3-acetate for 30 weeks. Comparisons of the percentage of mice with tu...

The metabolism of fluorene, a tricyclic aromatic hydrocarbon, by Cunninghamella elegans ATCC 36112 was investigated. Approximately 69% of the [9-14C]fluorene added to cultures was metabolized within 120 h. The major ethyl acetate-soluble metabolites were 9-fluorenone (62%), 9-fluorenol, and 2-hydroxy-9-fluorenone (together, 7.0%). Similarly to bacteria, C. elegans oxidized fluorene at the C-9 p...

chromanone derivatives demonstrate remarkable cytotoxity against a varieties of cancer cell lines. novel 9-[hydroxy(substitutedphenyl)methyl]-2,2-dimethyl-2,3,8,9- tetrahydro-4h,10h-pyrano[2,3-f]chromene-4,10-diones as glyasperin analogues were synthesized in four steps from known 4-chromone 1. the key step was the preparation of chromane dione 5a by regioselective intramolecular cyclization re...

The preferential cleavage of kynurenine peptides bonds was studied through reduction to y-(oaminophenyl)-homoserine derivatives followed by mild acidic as well as mild alkaline hydrolysis. The reduction of keto group of kynurenine to hydroxy one was achieved by controlled potential electrolysis at —1.05 Volts. In order to understand the mechanism of hydrolysis some model com­ pounds related to ...