Twenty-seven strains belonging to 12 Mycobacterium species were studied for 3-hydroxy fatty acid composition. Mycobacterial cells were subjected to both mild and strong acid methanolysis, after which the liberated hydroxy fatty acids were purified and analyzed by gas chromatography-mass spectrometry as methyl ester trimethylsilyl ether derivatives. Altogether, 21 3-hydroxy fatty acids containin...

Aging process begins from birth and continues during the lifetime. Skin aging is the result of some reactions in dermis, epidermis, pigment cells, hair follicles, sebaceous glands, blood vessels and secondary organs in the skin layers. In this case, the thickness of epidermis, which is the outmost layer of the skin, decreases, while the stratum corneum layer that is the outmost layer of the epi...

Lesquerella fendleri seed oil contains up to 60% hydroxy fatty acids, nearly all of which is the 20-carbon hydroxy fatty acid lesquerolic acid (D-14-hydroxyeicos-cis-11-enoic acid). Previous work suggested that lesquerolic acid in L. fendleri was formed by the elongation of the 18-carbon hydroxy fatty acid, ricinoleic acid. To identify a gene encoding the enzyme involved in hydroxy fatty acid e...

Ser (= /3-hydroxy Ala) belongs to the proteinogenic amino acids while other /3-hydroxy amino acids prevail in bacterial peptidic metabolites, often acting as Fe3+ chelating ligands. Thus, ß-hydroxy Asp is frequently encountered in the Pseudomonas siderophores (pyoverdins) [1], /3-Hydroxy Leu and 3-hydroxy-3-methyl Pro were recently found in a depsipeptide from Streptomyces sp. [2], L-Erythro-ß-...

The article describes a two-step synthesis of diastereomeric 3-hydroxy-2-methyl-3-(4-biphenylyl)butanoic acids. In the first step an intermediate alpha-bromo propanoic acid 1-ethoxyethyl ester was synthesized. The second step is a new modified Reformatsky reaction in presence of Zn in tetrahydrofuran (THF) at -5 to 10 degrees C between the previously synthesized intermediate and 4-acetylbipheny...

Correction for ‘Stereo-selective synthesis of non-canonical γ-hydroxy-α-amino acids by enzymatic carbon–carbon bond formation’ Rui Zhang et al. , Catal. Sci. Technol. 2021, 11 7380–7385, https://doi.org/10.1039/D1CY00955A.

Studies of extracellular and intracellular n-Lu-hydroxy acids produced by Lactobadlus casei 7469 were prompted by the earlier discovery that certain nutritional mutants derived from this organism, notably L. casei 280-16 and 280-16A (l-3), give a growth response to any one of a wide variety of n-ac-hydroxy acids. n-Lactic acid is the simplest growth-promoting acid for these organisms, although ...

2-Hydroxy fatty acids are relatively minor species of membrane lipids found almost exclusively as N-acyl chains of sphingolipids. In mammals, 2-hydroxy sphingolipids are uniquely abundant in myelin galactosylceramide and sulfatide. Despite the well-documented abundance of 2-hydroxy galactolipids in the nervous system, the enzymatic process of the 2-hydroxylation is not fully understood. To fill...

In microorganisms hydroxy fatty acids are produced from the biotransformation of unsaturated fatty acids. Such compounds belong to a class of oxylipins which are reported to perform a variety of biological functions such as anti-inflammatory or cytotoxic activity. These compounds have been found in rice and timothy plants after being infected by specific fungus. When grown in submerged culture ...