NM, JR, DE, DR, MP: Department of Biochemistry and Molecular Biology, Merck Frosst Centre for Therapeutic Research, Kirkland, Quebec, Canada. DG, CB, TR: Department of Medicinal Chemistry, Merck Frosst Centre for Therapeutic Research, Kirkland, Quebec, Canada KO, SW, DN: Department of Comparative Medicine, Merck Frosst Centre for Therapeutic Research, Kirkland, Quebec, Canada. Molecular Pharmac...

BACKGROUND The labile nature of live, attenuated varicella-zoster virus (Oka/Merck) requires robust stabilization during virus bulk preparation and vaccine manufacturing in order to preserve potency through storage and administration. One stabilizing ingredient used in a varicella-zoster virus (VZV) vaccine is hydrolyzed porcine gelatin which represents the major protein/peptide-based excipient...

Department of Biochemistry and Center in Molecular Toxicology, Vanderbilt University School of Medicine, Nashville, TN (M.B., F.P.G.); Merck-Serono, RBM S.p.A. Instituto di Ricerche Biomediche A. Marxer, Colleretto Giacosa, TO, Italy (L.B., S.R.); Merck-Serono, Global Early Development, Darmstadt, Germany (H.D.); and Merck-Serono, Global Early Development, Darmstadt/Global DMPK, Grafing, German...

Intravenous infusion of hydrochloric acid was used as a safe, effective, and quantitative method for correction of metabolic alkalosis in two patients. The first shows the risks of intravenously administered ammonium chloride, the currently available alternative to hydrochloric acid therapy. The second shows the efficacy of intravenously administered hydrochloric acid. While breathing spontaneo...

1Global DMPK, Innovative Medicines, AstraZeneca R&D, Södertälje, Sweden; 2Current affiliation: Merck Research Laboratories, Merck & Co., Inc., Upper Gwynedd, PA, USA; 3European Medicines Agency, London, UK; 4Division of Pharmacology, Leiden Academic Center for Drug Research, Leiden University, Leiden, The Netherlands; 5M&S, Merck Sharp & Dohme, Oss, The Netherlands. Correspondence: SAG Visser (...

Females Aged 9-21 Years in the United States, 2007-2012 Dongmu Zhang, PhD; Nagesh N. Borse, PhD, MS, BS Pharm; Amit S. Kulkarni, PhD; Linda Niccolai, PhD ScM; Global Health Outcomes, Merck and Co. Inc., West Point, PA; Global Health Outcomes, Agile 1 For Merck and Co., West Point, PA; Global Health Outcomes Vaccine, Merck and Co. Inc., Whitehouse Station, NJ; Yale School of Public Health, Yale ...

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