Physical and chemical methods were used to characterize hyaluronic acid before (fraction HAIIBI) and after (fraction HA-AA) treatment with ascorbic acid. Fraction HA-AA was recovered with an almost quantitative yield and was shown to be chemically identical with fraction HAIIBI by all the methods used. These two materials, however, differed markedly in their molecular sizes and degree of polydi...

Given the wide difference in price per vial between various presentations of hyaluronic acid, this study seeks to compare the effectiveness and treatment cost of stabilized hyaluronic acid (NASHA) in a single injection with standard preparations of hyaluronic acid (HA) in five injections in osteoarthritis (OA) of the knee. Fifty-four patients with knee osteoarthritis (Kellgren-Lawrence Grade II...

Hepatic fibrosis; chronic hepatitis C; HCV genotype 4; serum hyaluronic acid (HA); serum Collagen type IV (Coll-IV); AST to platelet ratio index (APRI) and Receiver operating characteristics

The inherent radioresistance and inaccuracy of localization of tumors weaken the clinical implementation effectiveness of radiotherapy. To overcome these limitations, hyaluronic acid-functionalized bismuth oxide nanoparticles (HA-Bi2O3 NPs) were synthesized by one-pot hydrothermal method for target-specific computed tomography (CT) imaging and radiosensitization of tumor. After functionalizatio...

Hyaluronic acid (HA) is a major component of cartilage extracellular matrix and is an attractive material for use as 3D injectable matrices for cartilage regeneration. While previous studies have shown the promise of HA-based hydrogels to support cell-based cartilage formation, varying HA concentration generally led to simultaneous changes in both biochemical cues and stiffness. How cells respo...

Biomaterials are playing a vital role in our day-to-day life. Hyaluronan (hyaluronic acid), a biomaterial, receives special attention among them. Hyaluronic acid (HA) is a polyanionic natural polymer occurring as linear polysaccharide composed of glucuronic acid and N-acetylglucosamine repeats via a β-1,4 linkage. It is the most versatile macromolecule present in the connective tissues of all v...

CD44 is the canonical receptor for hyaluronic acid (HA) but is capable of binding other ligands such as osteopontin (OPN) [1-3]. CD44-HA interactions are important mediators of the inflammatory response associated with immune cell development, differentiation, and recruitment [4]. In addition to the standard CD44 receptor (CD44s), CD44 can undergo alternative splicing to form CD44 variants (CD4...

Hyaluronic acid (HA or hyaluronan) is a natural, high molecular weight, linear polysaccharide composed of alternating N-acetyl glucosamine and glucuronic acid disaccharide units. HA is ubiquitous in human and animal tissues. It is found in the vitreous body, in the extracellular matrix of soft connective tissues, and in the synovial fluids. By supplementing the body’s level of glycosaminoglycan...

bovine oocytes matured in culture were denuded from cumulus cells with hyaluronidase and by repeat pipetting trough a fine pasture pipete and were inseminated with frozen-thawed spermatozoa in a protein-free bo medium containing 5m m-caffeine, l0 mg heparin/ml and with or without polyvinyl pyrrolidone (pvp) and different concentrations of hyaluronic acid. when oocytes were inseminated in the ab...

The tumor targetability and stimulus responsivity of drug delivery systems are crucial in cancer diagnosis and treatment. In this study, hepatoma-targeting mixed micelles composed of a hyaluronic acid-glycyrrhetinic acid conjugate and a hyaluronic acid-l-histidine conjugate (HA-GA/HA-His) were prepared through ultrasonic dispersion. The formation and characterization of the mixed micelles were ...