BACKGROUND References to neurologic disorders are frequently found in fictional literature and may precede description in the medical literature. AIM Our aim was to compare Charlotte Brontë's depiction of Bertha Mason in Jane Eyre to the tenets set forth in George Huntington's original essay "On chorea" with the hypothesis that Mason was displaying features of Huntington disease. RESULTS Ch...

Huntington disease has been linked to increased dopaminergic neurotransmission in the striatum, and clinical studies have demonstrated that the associated chorea can be treated with dopamine antagonist or dopamine-depleting drugs. The origin of this hyperdopaminergic status is unknown. Because substantia nigra pars compacta and the ventral tegmental area are the main sources of striatal dopamin...

References: [1] E.J. Slow, et al, “Selective striatal neuronal loss in a YAC128 mouse model of Huntington disease.,” Hum Mol Genet, vol. 12, 2003, p. 1555―67. [2] J.M. Van Raamsdonk, et al, “Selective degeneration and nuclear localization of mutant huntingtin in the YAC128 mouse model of Huntington disease.,” Hum Mol Genet, vol. 14, 2005, p. 3823―35. [3] J.P. Lerch, et al, “Automated deformatio...

Abstract Following the introduction of dicamba-resistant (DR) soybean in 2017, concerns have increased with regard to dicamba off-target movement (OTM) onto sensitive crops, including vegetables. Field trials were conducted New Jersey, York, and Delaware evaluate cucumber (‘Python’), eggplant (‘Santana’), snap bean (‘Caprice’ ‘Huntington’) injury yield response simulated drift rates. Crops expo...

BACKGROUND AND PURPOSE In patients with premanifest (nonsymptomatic) and advanced Huntington disease, changes in brain iron levels in the basal ganglia have been previously reported, especially in the striatum. Quantitative susceptibility mapping by using MR phase imaging allows in vivo measurements of tissue magnetic susceptibility, which has been shown to correlate well with iron levels in br...

PURPOSE To test the hypothesis that the T2 shortening observed on MR images of the brain in patients with Parkinson and Huntington diseases is due to tissue iron deposition. METHODS Tissue iron and ferritin assays were performed on postmortem putamen and globus pallidus samples from subjects with Huntington and Parkinson disease. The assays were correlated with T2 measurements. Normal samples...

Huntington’s disease is characterized after onset by uncoordinated jerky body movements along with a decline in selected mental capabilities including considerable variation between individuals with the condition. The global prevalence of the condition is approximately one person in 14,000 with considerable variations between geographical locations. Onset of Huntington’s disease is more common ...