lymphocytes (T cells) play critical roles in the regulation of immune responses, and are responsible for mediating many of the effector mechanisms of the immune system. For this reason, there has always been a need for assays to measure accurately the activity of populations of T cells, both in model (animal) systems and in humans. The expansion of the biotechnology industry has led to a dramat...

We have studied the effects of human alpha-fetoprotein (HAFP), isolated from the serum and ascitic fluid of a hepatoma-bearing patient, on the in vitro transformation of human peripheral blood lymphocytes by a variety of mitogenic stimuli. At a concentration of 2.5 mg/ml, HAFP inhibited the lymphocyte response to phytohemagglutinin, concanavalin A, and rabbit anti-human thymocyte serum, but fai...

This study was undertaken to localize the enzyme cyclic 3’,5’-adenosine monophosphatase in unstimulated human small lymphocytes. Cyclic AMP may be of importance in mediating lymphocyte stimulation, hence localization of the enzyme that is thought to modulate its intracellular concentration, cyclic AMPase, may point to the site of action of cyclic AMP in the cell. The histochemical technique

In this study, the cytogenetic effects of a sulphonylurea group herbicide Logran (effective substance; Triasulfuron) were investigated in human peripheral blood lymphocyte culture. The cultures were treated with 2, 4, 8, 16, 32, 64, 128, and 256 mg/ml concentrations of Logran for 24 and 48 h. This compound increased chromosome aberrations (CA) in human lymphocyte culture. Logran decreased Mitot...