background the human leukocyte antigen (hla) system is widely used as a strategy in the search for the etiology of renal function impairment. objectives this study was carried out to detect the most common hla alleles’ distribution in kidney transplant in both donors and recipients, and clarify the association between hla alleles and renal dysfunction immediately after transplantation. patients...

OBJECTIVES Although previous studies have investigated the effect of human leukocyte antigen matching on long-term outcomes after heart transplants, its role in the prognosis after a heart transplant remains unclear, particularly with respect to short-term survival. MATERIALS AND METHODS We evaluated the human leukocyte antigen mismatch on in-hospital mortality of 158 consecutive patients who...

Human Leukocyte Antigen (HLA) complexes are critical cell-surface protein assemblies that facilitate T-cell surveillance of almost all cell types in the body. While receptor binding to HLA class I and II is well-described with detailed structural information, nature cis interactions within plasma membrane surveyed cells remains be better characterized, as protein-protein environment technically...

Direct effects of Helicobacter pylori (H. pylori) on human CD4+ T-cells hamper disentangling a possible bacterial-mediated interference with major histocompatibility complex class II (MHC-II)-dependent antigen presentation to these cells. To overcome this limitation, we employed a previously described assay, which enables assessing human antigen-processing cell function by using murine T-cell h...

CONTEXT Chronic hepatitis B infection is the leading cause of cirrhosis and hepatocellular carcinoma. Human leukocyte antigen may be involved in the chronicity of hepatitis B virus (HBV) infection. OBJECTIVE To analyze the association between HBV chronicity and human leukocyte antigen alleles and haplotypes of 636 organ donors and recipients. DESIGN Subjects were categorized into 2 groups a...

During recent years, increasing evidence has accumulated that preformed antidonor human leukocyte antigen (HLA) class II antibodies represent significant risk factors for transplant dysfunction and failure (1– 6). Also, the posttransplant development of anticlass II antibodies is associated with a higher incidence of acute and chronic rejection (7–14). In this issue, the report by Issa et al. (...

Polymorphnuclear neutrophils (PMN) possess a very short half-life in the circulation because they constitutively undergo apoptosis (Gasmi et al., 1996; Stringer et al., 1996; Moulding et al., 1998). Under certain conditions PMN play an important role in the effectors arm of host immune defense through the clearance of immune complexes, the phagocytosis of opsonized particles, and the release of...

........................................................................................ 9 INTRODUCTION ................................................................................. 11 REVIEW OF THE LITERATURE .............................................................. 12 1 KIDNEY TRANSPLANTATION .............................................................. 12 1.1 General aspects of kid...

Background: Papillon-Lefevre syndrome (PLS) is a rare autosomal recessive disorder characterized by palmoplantar hyperkeratosis and early development of aggressive pe-riodontitis. Although cathepsin C (CTSC) gene mutations have been established in about 70-80% of PLS patients, it is assumed that the patients may have dysfunctioning of immune defense mechanisms. Objective: To assess the associat...

Background: A common Human Leukocyte Antigen (HLA) class II allele, DQβ1*03:01, seems to be associated with Bullous pemphigoid (BP) in Caucasians whereas previous studies in other ethnic groups showed other HLA class II alleles as genetic predisposing factors for BP. Objective: To investigate the association of HLA class II alleles and haplotypes with BP in Iranian population. Methods: Fifty pa...