OBJECTIVES Alterations in mitochondrial DNA (mtDNA) copy number have been widely reported in various human cancers, and been considered to be an important hallmark of cancers. However, little is known about the value of copy number variations of mtDNA in the prognostic evaluation of laryngeal cancer. DESIGN AND METHODS Using real-time quantitative PCR method, we investigated mtDNA copy number...

BACKGROUND MicroRNA-23a (miR-23a) has been demonstrated to play an important role in the development of several types of cancer, but its role in tumorigenesis of laryngeal carcinoma is still unclear. The aim of this study was to investigate the expression patterns and clinical implications of miR-23a in laryngeal cancer. METHODS Quantitative RT-PCR was performed to evaluate the expression lev...

To discover candidate biomarkers for diagnosis and detection of human laryngeal carcinoma and explore possible mechanisms of this cancer carcinogenesis, two-dimensional strong cation-exchange/reversed-phase nano-scale liquid chromatography/mass spectrometry analysis was used to identify differentially expressed proteins between the laryngeal carcinoma tissue and the adjacent normal tissue. As a...

PURPOSE OF REVIEW One fifth of cancers worldwide are associated with viral infection. Indeed, the causal link between human papillomavirus and cervical carcinoma is so well established that it is thought to be the first necessary cause of human cancer ever identified. One of the primary aims of research in this area is to reduce cancer prevalence by vaccination. However, the role that human pap...

Gastroesophageal reflux disease (GERD), or its variation known as laryngopharyngeal reflux (LPR), has been recognized as a potential cause of several laryngeal disorders. Patients with laryngeal cancer have lifestyle risk factors, especially tobacco and alcohol consumption, that play an etiological role in the development of their cancer but also places them at risk for reflux. The question the...

We firstly conducted a case-control study to investigate the role of two SNPs in MLL3 gene (rs6943984 and rs4725443) in the development of laryngeal cancer in a Chinese population. Between May 2012 and October 2014, a total of 171 patients with laryngeal cancer and 251 control subjects were collected from the Zhumadian Central Hospital. Genotyping of MLL3 rs6943984 and rs4725443 were analyzed u...

background laryngeal cancer though accounts for only 1.5% of all malignant neoplasm. scientific evidence has shown that cancers of the oral cavity, larynx, lung and esophagus are associated with cigar smoking. the present study is to examine by case-control method the impact of smoking on laryngeal cancer. material and methods one hundred and six hospitalized cases of otolaryngology department ...