One of the most important attributes of the polymerase chain reaction (PCR) is its exquisite sensitivity. However, the high sensitivity of PCR also renders it prone to falsepositive results because of, for example, exogenous contamination. Good laboratory practice and specific anti-contamination strategies are essential to minimize the chance of contamination. Some of these strategies, for exam...

After spinal cord injury (SCI) of the cat or rat neuronal centres below the level of lesion exhibit plasticity that can be exploited by specific training paradigms. In individuals with complete or incomplete SCI, human spinal locomotor centers can be activated by appropriate afferent input. This includes to facilitate and assist stepping movements of the legs and to provide body weight support ...

OBJECTIVE To describe the experience of strengthening laboratory diagnosis of tuberculosis (TB) in a resource-limited country with high TB-HIV (human immunodeficiency virus) and multidrug-resistant TB (MDR-TB) prevalence. METHODS In the Kingdom of Lesotho, which is confronted with high levels of TB, MDR-TB and HIV prevalence, between 2006 and 2008 a coalition of the Foundation for Innovative ...

In 2007, after 6 years of postdoctoral training at the University of Toronto, I was extremely fortunate to be offered an Assistant Professor position in the Department of Physiology at the University of Alberta, Edmonton. Transitioning from a postdoctoral training to an independent investigator position is both extraordinarily exciting and terrifying. On one hand, one has a whole career ahead w...

Mutation detection plays an increasingly significant role in clinical diagnostic testing, posing formidable challenges for laboratories. The expanding indications for clinical molecular testing and the nuances of interpreting test results are discussed. Methods for screening mutation detection platforms and monitoring assay reliability are presented, and results of platform comparisons are desc...