نتایج جستجو برای: hsv1

تعداد نتایج: 375  

2015
Parichehr Ghalayani Fateme Rashidi Zahra Saberi

OBJECTIVES Regarding the implication of viruses particularly herpes in pemphigus vulgaris, we sought to assess and compare the level of immunoglobulin G (IgG) antibodies against herpes simplex virus types 1 and 2 (HSV1 and HSV2), cytomegalovirus (CMV) and Epstein-Barr virus (EBV) in patients with pemphigus vulgaris and healthy people. MATERIALS AND METHODS In this cross-sectional study, 25 pa...

Journal: :Cancer research 1998
J G Tjuvajev N Avril T Oku T Sasajima T Miyagawa R Joshi M Safer B Beattie G DiResta F Daghighian F Augensen J Koutcher J Zweit J Humm S M Larson R Finn R Blasberg

We report a series of studies that assess the feasibility and sensitivity of imaging of herpes virus type one thymidine kinase (HSV1-tk) gene transfer and expression with [124I]-5-iodo-2'-fluoro-1-beta-D-arabinofuranosyluracil ([124I]-FIAU) and positron emission tomography (PET) and the ability of [124I]-FIAU-PET imaging to discriminate different levels of HSV1-tk gene expression. Studies were ...

Journal: :Molecular vision 2005
Anshoo Choudhary Paul Hiscott Charles A Hart Stephen B Kaye Mark Batterbury Ian Grierson

PURPOSE Stromal vascularization is a frequent occurrence in herpes simplex keratitis (HSK) and carries a poor prognosis for penetrating keratoplasty. The pathogenesis may involve disruption of the normal equilibrium between angiogenic and anti-angiogenic factors in and around the cornea. Thrombospondin (TSP) 1 and 2 are multifunctional matricellular glycoproteins with potent anti-angiogenic pro...

Journal: :Circulation 2002
Joseph C Wu Masayuki Inubushi Gobalakrishnan Sundaresan Heinrich R Schelbert Sanjiv S Gambhir

BACKGROUND Imaging reporter gene expression is useful for noninvasive monitoring of gene therapy. In this study, we imaged cardiac reporter gene expression in living rats using micro positron emission tomography (microPET). METHODS AND RESULTS Rats (n=10) underwent intramyocardial injection with 1x10(9) pfu of adenovirus carrying cytomegalovirus promoter-driving herpes simplex virus type 1 mu...

2017
Anna Buch Oliver Müller Lyudmila Ivanova Katinka Döhner Dagmara Bialy Jens B Bosse Anja Pohlmann Anne Binz Maike Hegemann Claus-Henning Nagel Martin Koltzenburg Abel Viejo-Borbolla Bodo Rosenhahn Rudolf Bauerfeind Beate Sodeik

Upon reactivation from latency and during lytic infections in neurons, alphaherpesviruses assemble cytosolic capsids, capsids associated with enveloping membranes, and transport vesicles harboring fully enveloped capsids. It is debated whether capsid envelopment of herpes simplex virus (HSV) is completed in the soma prior to axonal targeting or later, and whether the mechanisms are the same in ...

Journal: :Blood 2012
Michael R Sutherland Wolfram Ruf Edward L G Pryzdial

The coagulation system provides physiologic host defense, but it can also be exploited by pathogens for infection. On the HSV1 surface, host-cell-derived tissue factor (TF) and virus-encoded glycoprotein C (gC) can stimulate protease activated receptor 1 (PAR1)-enhanced infection by triggering thrombin production. Using novel engineered HSV1 variants deficient in either TF and/or gC, in the pre...

2011
Gerard ILL-Raga Ernest Palomer Matthew A. Wozniak Eva Ramos-Fernández Mònica Bosch-Morató Marta Tajes Francesc X. Guix José J. Galán Jordi Clarimón Carmen Antúnez Luis M. Real Mercé Boada Ruth F. Itzhaki César Fandos Francisco J. Muñoz

BACE1 is a key enzyme involved in the production of amyloid ß-peptide (Aß) in Alzheimer's disease (AD) brains. Normally, its expression is constitutively inhibited due to the presence of the 5'untranslated region (5'UTR) in the BACE1 promoter. BACE1 expression is activated by phosphorylation of the eukaryotic initiation factor (eIF)2-alpha, which reverses the inhibitory effect exerted by BACE1 ...

Journal: :Journal of nuclear medicine : official publication, Society of Nuclear Medicine 2008
Véronique Roelants Daniel Labar Carole de Meester Xavier Havaux Antonio Tabilio Sanjiv S Gambhir Mauro Di Ianni Anne Bol Luc Bertrand Jean-Louis Vanoverschelde

UNLABELLED Mesenchymal stem cells (MSCs) are a promising cell line for the treatment of ischemic heart disease. To evaluate the success of their transplantation into living animals, noninvasive imaging techniques that are able to track the distribution and fate of those cells would be useful. The aim of this study was to investigate the feasibility of infecting rat MSCs with adenoviruses and re...

Journal: :Journal of virology 2008
Claus-Henning Nagel Katinka Döhner Mojgan Fathollahy Tanja Strive Eva Maria Borst Martin Messerle Beate Sodeik

To analyze the assembly of herpes simplex virus type 1 (HSV1) by triple-label fluorescence microscopy, we generated a bacterial artificial chromosome (BAC) and inserted eukaryotic Cre recombinase, as well as beta-galactosidase expression cassettes. When the BAC pHSV1(17(+))blueLox was transfected back into eukaryotic cells, the Cre recombinase excised the BAC sequences, which had been flanked w...

Journal: :Circulation 2004
Ian Y Chen Joseph C Wu Jung-Jun Min Gobalakrishnan Sundaresan Xiaoman Lewis Qianwa Liang Harvey R Herschman Sanjiv S Gambhir

BACKGROUND We have previously validated the use of micro-positron emission tomography (microPET) for monitoring the expression of a single PET reporter gene in rat myocardium. We now report the use of a bicistronic adenoviral vector (Ad-CMV-D2R80a-IRES-HSV1-sr39tk) for linking the expression of 2 PET reporter genes, a mutant rat dopamine type 2 receptor (D2R80a) and a mutant herpes simplex viru...

نمودار تعداد نتایج جستجو در هر سال

با کلیک روی نمودار نتایج را به سال انتشار فیلتر کنید