The Human Phenotype Ontology (HPO) provides a conceptualization of phenotype information and a tool for the computational analysis of human diseases. It covers a wide range of phenotypic abnormalities encountered in human diseases and its terms (classes) are structured according to a directed acyclic graph. In this context the prediction of the phenotypic abnormalities associated to human genes...

OBJECTIVE To assess the influence of anatomical location on computed tomography (CT) numbers in mid- and full field of view (FOV) cone beam computed tomography (CBCT) scans. STUDY DESIGN Polypropylene tubes with varying concentrations of dipotassium hydrogen phosphate (K₂HPO₄) solutions (50-1200 mg/mL) were imaged within the incisor, premolar, and molar dental sockets of a human skull phantom...

The quality of a model induced by a learning algorithm is dependent upon the training data and the hyperparameters supplied to the learning algorithm. Prior work has shown that a model’s quality can be significantly improved by filtering out low quality instances or by tuning the learning algorithm hyperparameters. The potential impact of filtering and hyperparameter optimization (HPO) is large...

Hypertrophic pulmonary osteoarthropathy (HPO) associated with non-small cell lung cancer in a 58-year-old man was accompanied by an elevated serum level of growth hormone (GH). HPO rapidly disappeared after resection of the primary tumor and the elevation of serum GH was resolved. Immunohistochemically the tumor contained growth hormone-releasing hormone (GHRH) but not GH. These findings sugges...

The Human Phenotype Ontology (HPO) is a controlled vocabulary which provides phenotype data related to genes or diseases. The Health Terminology/Ontology Portal (HeTOP) is a tool dedicated to both human beings and computers to access and browse biomedical terminologies or ontologies (T/O). The objective of this work was to integrate the HPO into HeTOP in order to enhance both works. This integr...

The geomagnetic activity index Kp is widely used but restricted by low time resolution (3-hourly) and an upper limit. To address this, new indices, Hpo, are introduced. Similar to Kp, Hpo expresses the level of planetary in units thirds (0o, 0+, 1−, 1o, 1+, 2−, …) based on magnitude disturbances observed at subauroral observatories. has a higher than Kp. 30-min (Hp30) 60-min (Hp60) indices prod...

Hepatopoietin (HPO) is a novel polypeptide mitogen specific for hepatocytes and hepatoma cell lines, which is derived from liver and supports its regeneration. To determine whether HPO acts via a receptor-based signal transduction, recombinant human hepatopoietin was labeled by iodination and used to characterize its binding activity by specific displacement test and Scatchard analysis in prima...

The Human Phenotype Ontology (HPO) is a structured repository of concepts (HPO Terms) that are associated to one or more diseases. The process of association is referred to as annotation. The relevance and the specificity of both HPO terms and annotations are evaluated by a measure defined as Information Content (IC). The analysis of annotated data is thus an important challenge for bioinformat...

The DRE/DREF transcriptional regulatory system has been demonstrated to activate a wide variety of genes with various functions. In Drosophila, the Hippo pathway is known to suppress cell proliferation by inducing apoptosis and cell cycle arrest through inactivation of Yorkie, a transcription co-activator. In the present study, we found that half dose reduction of the hippo (hpo) gene induces e...