The most common approach for achieving sustained drug release is by the use of hydrophilic polymeric excipients directly compressed with active ingredients into tablets. Hydrophilic polymers swell in the presence of water to form hydrogel structures from which drugs are released by slow diffusion. The purpose of this study was to prepare a floating drug delivery system of levofloxacin, a fluoro...

Hydrophilic matrices, especially HPMC based, are widely used to provide sustained delivery where drug release occurs mainly by diffusion. A 3(2) full factorial design was used to develop and evaluate HPMC matrix tablet for sustained delivery of diclofenac. The influences of polymer concentration/viscosity, diluent type/ratio, drug load/solubility, compression force and pH change on drug release...

The aim of the present work was to develop a gastroretentive floating tablet of Atenolol and investigate the effects of both hydrophilic and hydrophobic retardant on in vitro release. Atenolol is an antihypertensive drug with an oral bioavailability of only 50% because of its poor absorption from lower gastrointestinal tract. The floating tablets of Atenolol were prepared to increase the gastri...

In present study, directly compressed controlled released matrix tablets of Diltiazem Hydrochloride were formulated at drug-to-polymer ratios (D: P) of 10:1, 10:2, 10:3 using polymers Ethocel 45 Premium, K100 LV Methocel, K15M EP Premium Methocel as rate controlling agents. In some formulations of Diltiazem hydrochloride and Ethocel 45 Premium matrices, 30% of filler was replaced by Co-excipien...

This investigation describes the preparation and in vitro evaluation of gastro retentive floating tablets of atorvastatin calcium. Two hydrophilic cellulose derivatives, Methocel K4M and Methocel K15M CR were used in floating tablets as gel forming agents to control drug release. Sodium bicarbonate and citric acid were incorporated as gas generating agents. The tablets prepared by direct compre...

The main objective of this research investigational studies is to formulate floating matrix tablets glimipride by applying simplex centroid design for optimization technique and direct compression method. Centroid configuration was drilled as an enhancement strategy adjusting the amount three components all while holding back their total concentration constant. Ingredients HPMC K15m, Kappa-carr...

In the current study, wet granulation with various concentrations and combinations of excipients like magnesium stearate as a lubricant, talc glident, DCP diluent, PVP K 30 binder successfully produced floating tablets rosiglitazone maleate. These included HPMC K15M, xanthan gum, sodium bicarbonate, tartaric acid gas-generating agents. We investigated every pre-compressional parameter, includin...

Gastroretentive drug delivery system i.e. floating microspheres of an H2 receptor antagonist drug ‘famotidine’ was successfully prepared using combination of polymer as hydroxyl propyl ethyl cellulose K15M (HPMC K15M) and cellulose acetate via non-aqueous solvent evaporation (oil-in-water) technique. Famotidine loaded floating microsphere formulations were prepared by dissolving polymer in solv...

The aim of the study was to develop and physicochemicaly characterize single unit controlled delivery system of Theophylline and was formulated as floating matrix tablet by direct compression method using gas generating agent (sodium bicarbonate) and various viscosity grades of hydrophilic polymers (HPMC K15M, K4M; HPC and Carbapol 934P). Formulation was optimized on the basis of buoyancy and i...