Much has been learned about the mechanisms underlying cellular senescence. The pathways leading to senescence appear to vary, depending on the cell type and cell culture conditions. In this respect, little is known about senescence of human peritoneal mesothelial cells (HPMC). Previous studies have significantly differed in the reported proliferative lifespan of HPMC. Therefore, in the present ...

In order to develop a kind of APAP double-release pellet capsules, which was prepared with the manual filling method, immediate and sustained release pellets certain proportion were by fluidized bed coating extrusion spheroidization process, respectively. It founded that both immediate-release sustained-release had smooth round surfaces. The particle size distribution ranged evenly from 16 35 m...

In the case of capsule-based dry powder inhalation systems (DPIs), selection appropriate capsule is important. The use gelatin, gelatin-PEG, and HPMC capsules has become widespread in marketed DPIs. We aimed to perform a stability test according ICH guideline above-mentioned three types. results novel combined formulated microcomposite were more favorable than those carrier-free formulation for...

Chronic peritoneal dialysis (PD) therapy is equally efficient as hemodialysis while providing greater patient comfort and mobility. Therefore, PD is the treatment of choice for several types of renal patients. During PD, a high-glucose hyperosmotic (HGH) solution is administered into the peritoneal cavity to generate an osmotic gradient that promotes water and solutes transport from peritoneal ...

In this study, an injectable bone substitute (IBS) consisting of citric acid, chitosan, and hydroxyl propyl methyl cellulose (HPMC) as the liquid phase and tetra calcium phosphate (TTCP), dicalcium phosphate dihydrate (DCPD) and calcium sulfate dehydrate (CSD, CaSO4 x 2H2O) powders as the solid phase, were fabricated. Two groups were classified based on the percent of citric acid in the liquid ...

In the present study the effect of Hydroxypropyl methylcellulose (HPMC) added to predust and batters of Talang queen fish (Scomberoides commersonnianus) nugget on the quality and its shelf life during four months of frozen storage were evaluated. The treatments consisted of control (without HPMC in coating), A (with 2%HPMC in pre-dust), B (with 2%HPMC in batter) and C (with 1% HPMC in pre-dust ...

BACKGROUND The glucose degradation products (GDP) presentin conventional peritoneal dialysis fluids (PDF) may exert adverse effects toward human peritoneal mesothelial cells (HPMC). Some GDP can be detoxified by the glyoxalase/ glutathione pathway. It has been shown that the addition of glyoxalase I (GLO-I) and reduced glutathione (GSH) to PDF effectively eliminates GDP. We have therefore exami...

A growing body of evidence indicates that epithelial-mesenchymal transition (EMT) of human peritoneal mesothelial cells (HPMC) may play an important role in the development and progression of peritoneal fibrosis during long-term peritoneal dialysis (PD) leading to failure of peritoneal membrane function. Here, we review our own observations and those of others on the mechanisms of EMT of HPMC a...

Soybean enriched rice based gluten free breads were designed incorporating a structuring agent (hydroxypropylmethylcellulose HPMC) and a processing aid (transglutaminase TG). At dough level the effect of increasing amounts of soybean protein isolate (SPI), HPMC and water was studied in the Mixolab. Mixing and thermal characteristics showed the significant effect induced by water, soybean protei...

Study aims to design a Gastro retentive Drug Delivery System of Cefuroxime axetil (CA). CA is a broad spectrum beta lactam type of antibiotic. More specifically, it is a second-generation cephalosporin. CA has site specific absorption from upper gastro intestinal tract and in intestine it undergoes hydrolysis to cefuroxime having poor absorption. Unabsorbed drug causes high concentration of ant...