BACKGROUND The definition of hereditary prostate cancer (HPC) is based on family history and age at onset. Intuitively, HPC is a serious subtype of prostate cancer but there are only limited data on the clinical phenotype of HPC. Here, we aimed to compare the prognosis of HPC to the sporadic form of prostate cancer (SPC). METHODS HPC patients were identified through a national registry of HPC...

Cloud computing is emerging as an additional deployment option for some of the HPC applications. But still, it currently does not come without drawbacks for application performance. These performance issues take place due to resource contention, where one VM is able to impact the performance of another. This interference directly creates impact on performance and scalability of HPC application....

MapReduce (MR) has become a de facto standard for largescale data analysis. Moreover, it has also attracted the attention of the HPC community due to its simplicity, efficiency and highly scalable parallel model. However, MR implementations present some issues that may complicate its execution in existing HPC clusters, specially concerning the job submission. While on MR there are no strict par...

We investigated the effects of stem cell factor (SCF) on the migration of murine bone marrow hematopoietic progenitor cells (HPC) in vitro using a modification of the checkerboard assay. Chemotactic and chemokinetic activities of SCF on HPC were evaluated by the numbers of HPC migrated on positive and negative gradients of SCF, respectively. On both positive and negative gradients of SCF, HPC b...

This paper examines the issue of High-Performance Computing (HPC) platforms in undergraduate education and the Bootable Cluster CD (BCCD) to facilitate hands-on, classroom immersion in HPC topics. There is measurable benefits derived from teaching HPC topics through providing hands-on clustering experience to the students. Supporting an HPC environment for instruction, however, is accompanied b...

We investigated whether vascular endothelial growth factor (VEGF) production by human pulp cells (HPC) is regulated by lipopolysaccharide (LPS) in relation to the pathogenesis of pulpitis. Although HPC incubated with medium alone only marginally expressed VEGF mRNA and produced a low level of VEGF as detected by enzyme-linked immunosorbent assay, the VEGF mRNA expression and VEGF production wer...

We developed a laboratory model of a unit of hemopoietic progenitor cells (mock-HPC unit) suitable for the validation of HPC cryopreservation procedures. The project was prompted by the practical and ethical difficulty of using real HPC units collected from healthy donors and patients for validation purposes. Mock-HPC units of different volumes ranging from about 120 to about 540mL were prepare...

We have recently demonstrated that tumor necrosis factor alpha (TNF-alpha) potentiates interleukin 3 (IL-3) and granulocyte/macrophage colony-stimulating factor-induced growth of CD34+ hematopoietic progenitor cells (HPC), and favors the generation of dendritic/Langerhans cells. The stimulatory effect of TNF-alpha was detailed in the present study. Thus, CD34+ HPC entering in cycle (S/G2M) afte...

OBJECTIVE AMP-activated protein kinase (AMPK) is an important regulator of multiple cellular pathways in the setting of energetic stress. Whether AMPK plays a critical role in hypoxic preconditioning (HPC), protecting cardiomyocytes against hypoxia reoxygenation (H/R) injury remains uncertain. METHODS H9c2 cells were preconditioned by exposing to 10 min of hypoxia and 30 min of reoxygenation....