The objective of this study was to determine if a high Tg polymer (Eudragit(®) S100) could be used to stabilize amorphous domains of polyethylene oxide (PEO) and hence improve the stability of binary polymer systems containing celecoxib (CX). We propose a novel method of stabilizing the amorphous PEO solid dispersion through inclusion of a miscible, high Tg polymer, namely, that can form strong...

In order to improve the aqueous solubility and dissolution of Tacrolimus (TAC), amorphous solid dispersions of TAC were prepared by hot melt extrusion with three hydrophilic polymers, Polyvinylpyrrolidone vinyl acetate (PVP VA64), Soluplus® and Hydroxypropyl Cellulose (HPC), at a drug loading of 10% w/w. Molecular modeling was used to determine the miscibility of the drug with the carrier polym...

OBJECTIVES The aim of this study was to develop mucoadhesive oral strips using hot-melt extrusion as a continuous manufacturing process. METHODS Powder blends of ketoconazole, a water-insoluble drug - either hydroxypropyl methylcellulose (HPMC) or soluplus (SOL), sorbitol (SRB) and magnesium aluminometasilicate (MAS) were extruded to manufacture thin strips with 0.5-mm thickness. The presence...

A study utilizing isotactic poly(4-methyl-1-pentene) (PMP) was undertaken to investigate a three stage process (melt-extrusion/annealing/uniaxial-stretching) (MEAUS) employed to produce microporous films. The results of this study will be reported in the course of two papers. In this first part, three PMP resins were melt-extruded into tubular films (blowup ratio; BUR = 1), where the resins eac...

A two part study utilizing polyoxymethylene (POM) was undertaken to investigate a three stage process (Melt-Extrusion/Annealing/Uniaxial-Stretching) (MEAUS) employed to produce microporous films. In this first part, three POM resins (D, E & F) were melt-extruded into tubular films (blowup ratio; BUR = 1), where resin D has a higher weight average molecular weight (Mw) than resin E but both poss...