Here, we assess the association between homocysteine (Hcy) serum levels and periodontal status in a large representative sample of National Health Nutrition Examination Survey (NHANES). Using 2001–2002 2003–2004 NHANES databases, participants with examination, medical self-reported data, blood pressure (BP) samples to determine complete count, C-reactive protein (CRP) Hcy levels. We then calcul...

A label-free molecularly imprinted electrochemical sensor (MIECS) based on electropolymerized polymer (MIP) was developed for the determination of homocysteine (Hcy) in serum first time. MXene@AuNPs with layered structure synthesized electrode by modifying MXene gold nanoparticles (AuNPs). MIP dopamine hydrochloride (DA) were onto surface modified molecular docking and quantum chemical calculat...

Several in vitro studies have showed the neurotoxic effect of homocysteine (Hcy) to various neuronal types, including cerebellar Purkinje neurons. In this study, we investigated whether the Hcy has neurotoxic effects on the rat pup’s cerebellum in the postnatal period that it continues to development. Pups rats divided into control and Hcy group. Hcy administration (0.3–0.6 mmol/g b...

Sir, Contradictory findings have recently been published, showing either a relation w1,2x or no relation w3x between plasma levels of homocysteine (Hcy) and vascular changes in dialysis patients. However, since Hcy accumulates in uraemic patients w4x and increased plasma Hcy levels are already present in the early stage of renal failure, a possible role for uraemia-associated hyperhomocysteinae...

Elevated level of plasma homocysteine (Hcy) has been identified as an independent risk factor for coronary artery disease (CAD). Furthermore, numerous studies have documented the influences of a common polymorphism (C677T) of methylenetetrahydrofolate reductase (MTHFR) on homocysteine levels. However the relationship between this mutation and cardiovascular diseases (CVD) has remained as a cont...

OBJECTIVES The aim of present study was to investigate serum homocysteine levels in apparently healthy vegetarians and ominvores in Mithi, district Tharparker, Sindh, Pakistan. METHODS This study was conducted in the Department of Biochemistry, Basic Medical Sciences Institute (BMSI), Jinnah Postgraduate Medical Center (JPMC), Karachi and blood samples were collected from Mithi, district Thar...

Elevated level of plasma homocysteine (Hcy) has been identified as an independent risk factor for coronary artery disease (CAD). Furthermore, numerous studies have documented the influences of a common polymorphism (C677T) of methylenetetrahydrofolate reductase (MTHFR) on homocysteine levels. However the relationship between this mutation and cardiovascular diseases (CVD) has remained as a cont...

BACKGROUND Hyperhomocysteinemia (HHcy) is a well-known risk factor for ischemic stroke. However, whether HHcy can influence the treatment outcome of acute ischemic stroke (AIS) patients has yet to be fully determined. In this study, we investigated the relationship between serum homocysteine (Hcy) level and prognosis in AIS patients who received tissue plasminogen activator (tPA) treatment. MAT...

BACKGROUND Multiple system atrophy (MSA) is a neurodegenerative disease, and its pathological hallmark is the accumulation of α-synuclein proteins. Homocysteine (Hcy) is an intermediate amino acid generated during the metabolism of methionine. Hcy may contribute to the pathogenesis of neurodegenerative disorders. Vitamin B12 and folate are cofactors necessary for the methylation of homocysteine...

In 1969, McCully reported an association between homocystinuria, a rare metabolic disorder characterized by high blood levels ( 100 mol/L) of the amino acid homocysteine (Hcy), and severe atherosclerosis among postmortem subjects.1 His report is widely recognized as the basis for the “homocysteine hypothesis,” namely, that elevated blood Hcy is a risk factor for cardiovascular disease (CVD). Si...