PURPOSE An important step in the development of liposome-based formulations is estimating the free drug concentration in the aqueous solution surrounding liposomes. This research presents a new method for determination of free concentrations, based on membrane-protected solid-phase microextraction (SPME). METHODS For effective direct extraction of low molecular weight compounds from complex l...

Thiazolidinedione, often shortened to TZD or glitazone, helps lower insulin resistance, which is the underlying problem for many people with type 2 diabetes. The two most known glitazones are pioglitazone (PGZ), brand name medicine Actos®, and rosiglitazone (RSG), Avandia®. This study presented a multivariate optimization in microextraction procedure employing Fractional Factorial Design (FFD) ...

Phase-matched four-wave mixing is demonstrated for millijoule nanosecond pulses guided by photonic bandgaps of hollow fibers with a two-dimensionally periodic cladding and a core diameter of 50 m. Raman resonances related to the stretching vibrations of water molecules inside the hollow fiber core are detected in the spectrum of the four-wave mixing signal, suggesting phase-matched coherent ant...

The dependence of the carrier-envelope (CE) phase of the pulses from a hollow-core fiber on the input laser energy was studied using two f-to- 2f interferometers. The CE phase in the in-loop f-to-2f interferometer was measured with the octave spanning white-light spectrum from the hollow-core fiber, whereas the out-of-loop interferometer was based on a sapphire plate. By modulating the input po...

since solid-phase and liquid-phase microextraction (spme and lpme) were introduced, as effective solvent-free methods, many efforts have been made to improve their modes and applications. however, due to limitations with sensitivity and efficiency, researchers have focused on improving the performance of their basic primary modes. in this way, in recent years, different methods such as ultrason...

A new procedure is presented for the determination of low concentrations of lead and cadmium in water samples. Ligand assisted pseudo-stir bar hollow fiber solid/liquid phase microextraction using sol-gel sorbent reinforced with carbon nanotubes was combined with differential pulse anodic stripping voltammetry for simultaneous determination of cadmium and lead in tap water, and Darongar river w...