Title of Document: ROLE OF NONCODING REGIONS IN NEWCASTLE DISEASE VIRUS REPLICATION AND PATHOGENESIS Yongqi Yan, Doctor of Philosophy, 2008 Directed By: Professor Siba K.Samal College of Veterinary Medicine The roles of the intergenic sequences (IGS) and untranslated regions (UTR) in Newcastle disease virus (NDV) transcription and pathogenesis are not clear. By our established reverse genetics ...

Background: Virulent Newcastle disease virus (vNDV) causes great economic losses to the poultry industry throughout the world. Despite the endemicity of Newcastle disease (ND) and occurrence of recurrent outbreaks, the nature and genetic features of circulating NDV strains in Iran are largely unknown. Aims: This study was conducted to characterize 13 NDV isolat...

Paramyxoviruses cause a wide variety of human and animal diseases. They infect host cells using the coordinated action of two surface glycoproteins, the receptor binding protein (HN, H, or G) and the fusion protein (F). HN binds sialic acid on host cells (hemagglutinin activity) and hydrolyzes these receptors during viral egress (neuraminidase activity, NA). Additionally, receptor binding is th...

Solid-phase extraction (SPE) of gallium(III) with hydrophobic 8-quinolinol derivatives (HQs)-impregnated resin from aqueous acidic and alkaline solutions has been investigated. The HQs used were 7-(4-ethyl-1-methyloctyl)-8-quinolinol (HEMOQ), 5-octyloxymethyl-8-quinolinol (HO(8)Q), 2-methyl-5-octyloxymethyl-8-quinolinol (HMO(8)Q), 5-dioctylaminomethyl-8-quinolinol (HN(8)Q), 7-bromo-5-octyloxyme...

In this article, we consider an analogue of Kenig and Stein's bilinear fractional integral operator on the Heisenberg group Hn. We completely characterize exponents α,β γ such that is bounded from Lp(Hn,|x|αp)×Lq(Hn,|x|βq) to Lr(Hn,|x|−γr). Also, analogous sharp results are obtained Euclidean space.

Newcastle disease virus (NDV), a member of the family Paramyxoviridae, has a nonsegmented negative-sense RNA genome consisting of six genes (3'-NP-P-M-F-HN-L-5'). The first three 3'-end intergenic sequences (IGSs) are single nucleotides (nt), whereas the F-HN and HN-L IGSs are 31 and 47 nt, respectively. To investigate the role of IGS length in NDV transcription and pathogenesis, we recovered v...

Caveolin 1 (Cav-1) is an integral membrane protein that forms the coat structure of plasma membrane caveolae and regulates caveola-dependent functions. Caveolae are enriched in cholesterol and sphingolipids and are related to lipid rafts. Many studies implicate rafts as sites of assembly and budding of enveloped virus. We show that Cav-1 colocalizes with the paramyxovirus parainfluenza virus 5 ...

Malignant tumors of head and neck carcinomas are the sixth most common type of cancer. Current systemic therapies for cancer show side effects in normal tissues and short-term efficacy due to drug resistance. Consequently, there is much interest in identifying new drugs for cancer treatment. Crocin (an active ingredient of saffron) has been shown to have cytotoxic effects on cancer cell lines. ...

In a recent letter to this journal, Depaulis and Veuille (1998) discussed two possible tests of neutrality, the ‘‘haplotype number test’’ and the ‘‘haplotype diversity test.’’ They present in their tables 1 and 2 means and percentage points of the distribution of the number Kn of haplotypes and the sample heterozygosity Hn 5 1 2 , where p1, . . . , are the relative frequenK 2 n S p p i51 i Kn c...