background: human leukocyte antigen-g (hla-g) is a non-classical class i molecule highly expressed by extravillous cytotrophoblast cells. due to a single base pair deletion, its function can be compensated by other isoforms. investigating the frequency of null allele in recurrent miscarriage (rm) subjects could be useful in understanding the relationship between frequency of this allele and rm ...

UNLABELLED HIV-1 Nef binds to the cytoplasmic region of HLA-A and HLA-B and downregulates these molecules from the surface of virus-infected cells, thus evading immune detection by CD8(+) T cells. Polymorphic residues within the HLA cytoplasmic region may affect Nef's downregulation activity. However, the effects of HLA polymorphisms on recognition by primary Nef isolates remain elusive, as do ...

the human leukocyte antigen g (hla-g) molecule exhibits limited tissue distribution, low polymorphism and alternative splicings that generate seven hla-g isoforms. hla-g exerts multiple immunoregulatory functions. recent studies indicate an ectopic up-regulation in tumor cells that may favor their escape from anti-tumor immune responses. this study it is an effort to clarify the presence of hla...

human leukocyte antigen-g which is an immune tolerance effecter molecule has an important role in the maintenance of fetus during pregnancy. abortion is one of the complications of pregnancy period.  in this research, we have studied levels of hla-g 5, hla-g7 isoforms in the abortion-threatened pregnant women in comparison with controls. in a case-control study, 101 abortion-threatened women an...

the human leukocyte antigen (hla)-g molecule is expressed in cytotrophoblast cells, adult thymic epithelial cells, erythroblasts, pancreatic islets and mesenchymal stem  cells. although, hla-g expression in allotransplanted patients is correlated with a better allograft acceptance, it is associated with an advanced grade of the tumor in cancer. in addition to the role on the immune system, hla-...

hla-g is a non-classical hla class ib molecule with limited protein variability generated by  alternative  splicing.  hla-g   displays  immunotolerant   properties  and  hence  plays important roles in the maintenance of a successful pregnancy and maternal tolerance of the semiallogenic fetus. polymorphism of the hla-g gene may potentially affect the biological properties of the protein, and a ...

The goal of this study was to characterize the molecular mechanisms underlying cetuximab-mediated upregulation of HLA class I antigen-processing machinery components in head and neck cancer (HNC) cells and to determine the clinical significance of these changes in cetuximab-treated HNC patients. Flow cytometry, signaling studies, and chromatin immunoprecipitation (ChIP) assays were performed us...