There are a number of polymorphism-based statistical tests of neutrality, but most of them focus on either the amount or the pattern of polymorphism. In this article, a new test called the two-dimensional (2D) test is developed. This test evaluates a pair of summary statistics in a two-dimensional field. One statistic should summarize the pattern of polymorphism, while the other could be a meas...

The urokinase receptor (uPAR) binds urokinase-type plasminogen activator (u-PA) through specific interactions with uPAR domain 1, and vitronectin through interactions with a site within uPAR domains 2 and 3. These interactions promote the expression of cell surface plasminogen activator activity and cellular adhesion to vitronectin, respectively. High molecular weight kininogen (HK) also stimul...

    Background: The aim of this study is to evaluate the geometry of the distal femur and the proximal tibia in the osteoarthritic knee using 3D reconstructive CT scan imaging. Methods: 449 patients with knee osteoarthritis were treated surgically in our center with patient-specific technology total knee arthroplasty. Preoperatively, all the patients underwent a CT scan according to a standard ...

High molecular weight kininogen (HK) and its domain 3 (D3) exhibit anticoagulant properties and inhibit platelet activation at low thrombin concentration in vitro. We hypothesized that the rapid occlusive thrombosis in HK-deficient (HKd) rats, following endothelial injury of the aorta, results from enhanced platelet aggregation by thrombin. The effects of D3 (G235-M357) or D3-derived peptides o...

<p class="abstract"><strong>Background:</strong> The aim of the study was to analyze and compare accuracy, efficiency functional evolution between first- second-generation Patient-specific instrumentation (PSI).</p><p class="abstract"><strong>Methods:</strong> We report our experience in TKA using PSI Visionaire System<sup>®</sup> (Smith Nep...

BACKGROUND The association between knee alignment and knee pain in knee osteoarthritis (OA) is unclear. High tibial osteotomy, a treatment option in knee OA, alters load from the affected to the unaffected compartment of the knee by correcting malalignment. This surgical procedure thus offers the possibility to study the cross-sectional and longitudinal association of alignment to pain. The aim...

Circadian rhythm is defined as a 24-hour biological oscillation, which persists even without any external cues but also can be re-entrained by various environmental cues. One of the widely accepted circadian rhythm behavioral experiment is measuring the wheel-running activity (WRA) of rodents. However, the price for commercially available WRA recording system is not easily affordable for resear...

The intercalated (IC) cells of the cortical collecting duct (CCD) are important to acid-base homeostasis by secreting acid and reabsorbing bicarbonate. Acid secretion is mediated predominantly by apical membrane Schering (SCH-28080)-sensitive H(+)-K(+)- ATPase (HKA) and bafilomycin-sensitive H(+)-ATPase. The SCH-28080-sensitive HKA is believed to be the gastric HKA (HKAg). Here we examined apic...

background: the aim of this study is to evaluate the geometry of the distal femur and the proximal tibia in the osteoarthritic knee using 3d reconstructive ct scan imaging. methods: 449 patients with knee osteoarthritis were treated surgically in our center with patient-specific technology total knee arthroplasty. preoperatively, all the patients underwent a ct scan according to a standard prot...

This paper proposes an Improved Multi-phase Particle Swarm Optimization (IMPPSO) to solve a Dynamic Job Shop Scheduling Problem (DJSSP) known as non-deterministic polynomial-time hard (NP-hard) problem. A cellular neighbor network, velocity reinitialization strategy, randomly select sub-dimension and constraint handling function are introduced in the IMPPSO. The IMPPSO is used Kundakcı Kulak pr...