BACKGROUND Nasopharyngeal carcinoma (NPC) has a high incidence rate in Southern China. Although there are conventional therapies, the side effects and toxicities are not always tolerable for patients. Recently, the tumoricidal effect of ginsenosides on different cancer cells has been studied. This study aims to investigate the anti-cancer effect of ginsenosides on NPC cells and their underlying...

BACKGROUND The objective of this study was to investigate the influence of β2-microglobulin (β2-M) on the epithelial-mesenchymal transition (EMT) in renal tubular epithelial cells. METHODS A human kidney proximal tubular cell line (HK-2) was used as the proximal tubular cell model. HK-2 cells were exposed to different concentrations of β2-M (5, 10, 25, and 50 μM) for up to 24, 48 and 72 h. Th...

Benzene (C6H6) and toluene (C7H8) are toxic to humans and the environment. They are also important precursors of ground-level ozone and secondary organic aerosols and contribute substantially to severe air pollution in urban areas in China. Discrepancies exist between different bottom-up inventories for benzene and toluene emissions in the Pearl River Delta (PRD) and Hong Kong (HK), which are e...

Saha A, Hammond CE, Gooz M, Smolka AJ. IL-1 modulation of H,K-ATPase -subunit gene transcription in Helicobacter pylori infection. Am J Physiol Gastrointest Liver Physiol 292: G1055–G1061, 2007. First published January 4, 2007; doi:10.1152/ajpgi.00338.2006.—Helicobacter pylori infection of the human gastric body induces hypochlorhydria by perturbing acid secretion. H. pylori inhibits parietal c...

The tachykinin hemokinin-1 (HK-1) is involved in immune cell development and inflammation, but little known about its function pain. It acts through the NK1 receptor, several effects are mediated by a yet unidentified target. Therefore, we investigated role mechanism of action HK-1 arthritis models distinct mechanisms with special emphasis on Arthritis was induced i.p. K/BxN serum (passive tran...

The subloading-friction model is capable of describing static friction, the smooth transition from static to kinetic friction and the recovery to static friction after sliding stops or sliding velocity decreases. This causes a negative rate sensitivity (i.e. a decrease in friction resistance with increasing sliding velocity). A generalized subloading-friction model is formulated in this article...

The friction is detrimental to the normal work of the servo system, but the friction mechanism is very complicated. In this paper, Tustin friction model is used as the friction parameter identification, reflecting the phenomenon of friction in the system, and laying the foundation for the friction compensation. Tustin model is a nonlinear friction one, and the friction properties can be reflect...

The unstimulated platelet surface contains a specific and saturable binding site for high molecular weight kininogen (HK) and low molecular weight kininogen (LK). Investigations were performed with purified heavy and light chains of HK to determine which portion(s) of the HK molecule binds to the platelet surface. Purified 64-Kd heavy chain of HK and 56-Kd light chain of HK, independently, inhi...

This paper examines the effect of friction model on the simulation accuracy of a hydraulic cylinder by using three friction models: a steady-state friction model, the LuGre model, and the new modified LuGre model. Hydraulic cylinder’s behaviors were measured under sinusoidal input to the servo valve. Simulations were conducted under the same conditions as the experiments. The comparisons of sim...