lentiviral vectors are promising gene delivery tools capable of transducing a variety of dividing and non-dividing cells, including pluripotent stem cells which are refractory for transduction by murine retroviruses. although there is a growing debate on the safety of lentiviral vectors for gene transfer, in particular for those derived from human immunodeficiency viruses, type one (hiv-1) and ...

In an attempt to identify potential new agents that are active against HIV-1, a series of novel pyridopyrimidine-5-carbohydrazide derivatives featuring a substituted benzylidene fragment were designed and synthesized based on the general pharmacophore of HIV-1 integrase inhibitors. The cytotoxicity profiles of these compounds showed no significant toxicity to human cells and they exhibited anti...

O vírus da imunodeficiência humana do tipo 1 (HIV-1) é o agente etiológico AIDS. As hepatites virais B (HBV) e C (HCV) são infecções comuns em indivíduos HIV-positivos. Um dos fatores genéticos humanos investigados no controle replicação HIV-1 na progressão AIDS a enzima APOBEC3G (A3G). Pesquisas investigam sua ação HBV HCV. A resulta perda de informação genética produção virions defeituosos ci...

human immunodeficiency virus infection / acquired immunodeficiency syndrome (hiv/aids) is a disease pertained to the human immune system. given its crucial role in viral replication, hiv-1 protease (hiv-1 pr) is a prime therapeutic target in aids therapy. in this regard, the dynamic aspects of ligand-enzyme interactions may indicate an important role of conformational variability in hiv-1 pr in...

background helicobacter pylori (h. pylori) infection is common among humans and plays a major role in the etiology of peptic ulcer disease with significant morbidity in patients with hiv-1 on antiretroviral therapy. there are conflicting prevalence patterns of h. pylori in hiv-1 infected patients using various methods of detection. the noninvasive technique used for detection of h. pylori infec...

A few analogues of atevirdine or 1-[(5-methoxyindol-2-yl) carbonyl]-4-[3- (ethylamino)-2-pyridyl] piperazine – an anti-HIV belonging to non-nucleoside reverse transcriptase inhibitors were synthesized and evaluated for anti-HIV activity. Replacement of indolyl moiety with 2-alkylthio-1-benzyl-5-imidazolyl substituent afforded 1-[2-(alkylthio-1-benzyl-5-imidazolyl) carbonyl]-4-[3-(isopropylamino...