We present here a combined GC-MS and LC-MS metabolic profiling approach to unraveling the pathological outcomes of aristolochic acid (AA)-induced nephrotoxicity. Urine samples were analyzed by GC-MS and LC-MS in combination with pattern recognition techniques, e.g. principal component analysis (PCA), orthogonal projection to latent structure-discriminant analysis. The work indicates that AA-ind...

The periumbilical perforating pseudoxanthoma elasticum or perforating calcific elastosis is a rare disorder and its pathogenesis is associated with the alteration of elastic fibers, which may probably result from trauma. We present the case of a 70-year-old woman with long-time blackish maculas and keratotic surface papules on the periareolar and periumbilical regions. The histopathological exa...

the toxic impact of copper sulfate in lethal and sublethal concentrations was investigated on gill of grass carp, ctenopharynogodon idella . in this investigation, 27 specimens were used as control group and three treatment groups were treated with 2.5 and 5mg/l of copper sulfate. gill samples were collected from each treatment after 96hr and lesions were analyzed by light microscopy. in histop...

Rady, M.I.* and Amany M. Osman** J. Egypt. Soc. Toxicol. (Vol. 35: 19-25 July 2006) WWW.estoxicology.org * Department of Zoology, Faculty of Science, Al Azhar University and ** Department of Zoology, Girls College for Art, Science & Education, Ain Shams University ABSTRACT This study dealt with the evaluation of the histological alteration due to feeding on fried bread and the protective role...

schwannomas are benign neoplasms with unknown etiology, which apparently arise from neural sheath schwann cells. intraoral schwannomas are solitary, slow-growing lesions occurring at different ages; these lesions are normally asymptomatic and in some cases, they are accompanied by pain and paresthesia if spotted in the intraosseous regions of the mandibles. definitive diagnosis of schwannoma is...

Background: The aim of the present study was to find the effects of cadmium (Cd) on Japanese quail on the role of an animal model in order to understand the toxicity of Cd in creatures presented, within the environment. Methods: One hundred 30-day-old male Japanese quails were equally divided into the control group and Cd group. The control group received no Cd while the Cd group was given f...

Current strategies for the control of toxoplasmosis are based on chemotherapy, however successful vaccine has also been demonstrated. The present study aims to assess the effect of the vaccination with radiation-attenuated tachyzoites in challenged mice regarding histopathological alteration and DNA damage of hepatocytes. Sixty mice were equally divided as follow: Group I left as a normal contr...

BACKGROUND The signalment, clinicopathologic, bacteriological, histopathological, ultrasonographic characteristics, and the treatment and outcomes of adult cattle with cholangiohepatitis are poorly defined. ANIMALS Thirteen Holstein cows with cholangiohepatitis. METHODS Retrospective study of medical records of cattle admitted to the CHUV and the AVC between 1992 and 2012 and 2000 and 2012,...

Selective COX-2 inhibitors are most widely used analgesic and anti-inflammatory drugs;however, its maximal use is highly associated with various serious abnormal cardiovascularevents. Beraprost sodium (BPS), prostacyclin analogue has been shown to vasodilatory,antiplatelates, anti-inflmmatory, and antioxidant activity. The objective of the present study wasto evaluate the effect of BPS on celec...