Hydrodynamic methods provide a route for studying the low-resolution conformation--in terms of time-averaged spatial orientation of the Fab' and Fc domains relative to each other--of the human IgG subclasses, IgG1, IgG2, IgG3 and IgG4 in the environment in which many exist naturally---a solution. Representative modelling strategies are now available using 'shell-bead' or 'shell' modelling of th...

Intact rabbit immunoglobulin G molecules (IgGs) and their papain or pepsin fragments were radio-iodinated and injected into HeLa cells. Whole IgGs, Fab2, and Fc fragments were degraded with half-lives of 60-90 h, whereas half-lives of Fab fragments were 110 h. These results indicate that proteolytic cleavage in the hinge region of the IgG molecule is not the rate-limiting step in its intracellu...

Title of dissertation: CONTRIBUTIONS TO THE DYNAMICS OF HELICOPTERS WITH ACTIVE ROTOR CONTROL Carlos A. Malpica Doctor of Philosophy, 2008 Dissertation directed by: Professor Roberto Celi Department of Aerospace Engineering This dissertation presents an aeromechanical closed loop stability and response analysis of a hingeless rotor helicopter with a Higher Harmonic Control (HHC) system for vibr...

Movement in biology is an essential aspect of survival for many organisms, animals and plants. Implementing movement efficiently to meet specific needs is a key attribute of natural living systems, and can provide ideas for man-made developments. If we had to find a subtitle able to essentially convey the aim of this special section, it could read as follows: 'taking inspiration from nature for...

Design considerations and material selection play important roles in the development of surgical instruments. The substitution of shape memory or superelastic Nitinol for conventional materials used in instrumentation for endoscopic and interventional procedures can lead to a significant improvement in overall perfonnance of the instruments. Simplicity of design, reduced number of parts and eas...