نتایج جستجو برای: high dose modified release tablets
تعداد نتایج: 2662461 فیلتر نتایج به سال:
Formulation of gliclazide in the form of extendedrelease tablet in 30 and 60 mg dosage forms was performed using hypromellose (HPMC K4M) as a retarding agent. Drug-release profiles were investigated in comparison with references Diamicron MR 30 and 60 mg tablets. The effect of size of powder particles, the amount of hypromellose in formulation, hardness of tablets, and also the effect of halvin...
This paper reviews the use of texture analysis in studying the performance of hydrophilic matrices of highly soluble drugs and different types of excipients (i.e. water-soluble, water-insoluble and swellable, and water insoluble and non-swellable). Tablets were prepared by direct compression, and their swelling and erosion in presence of these different excipients were assessed with the help of...
The aim of present study was to prepare novel modified release press coated tablets of venlafaxine hydrochloride. Hydroxypropylmethylcellulose K4M and hydroxypropylmethylcellulose K100M were used as release modifier in core and coat, respectively. A 3(2) full factorial design was adopted in the optimization study. The drug to polymer ratio in core and coat were chosen as independent variables. ...
The objective of the present investigation was to study the effect of critical formulation parameters affecting release of isoxsuprine hydrochloride from matrix tablets using combination of polyethylene oxide (PEO) and dicalcium phosphate (DCP). The powder blend consisting of drug and excipients was analyzed for angle of repose, Carr’s index and Hausner’s ratio. The tablets were prepared by dir...
The aim of this work was to develop swellable modified release (MR) isoniazid tablets using different combinations of polyvinyl acetate (PVAc) and sodium-carboxymethylcellulose (Na-CMC). Granules were prepared by moist granulation technique and then compressed into tablets. In vitro release studies for 12 hr were carried out in dissolution media of varying pH i.e. pH 1.2, 4.5, 7.0 and 7.5. Tabl...
Tablet is most popular among all dosage forms today because of its convenience, ease administration, greater flexibility in form design, production, and low cost non-invasive therapy. Formulation tablets requires API along with excipients. Excipients include lubricants, diluents, binders, glidants, disintegrants, sweetening agents, flavoring etc. Recent trends indicate that multi-particulate dr...
Modified release formulations offer several advantages over conventional systems used in therapeutics. The aim of this work was to extend our previous studies on the chronobiotic hormone melatonin controlled release, by comparing its release from uncoated, compression-coated and bilayer tablets. Each tablet was comprised of melatonin and combinations of the following excipients: ethylcellulose,...
Objective: to study the pharmacokinetic parameters and safety of Dorsumio ® (mirtazapine + tizanidine, extended-release tablets, 15 mg 6 mg, JSC Valenta Pharm, Russia) taken once by healthy volunteers in comparison with Calixta , a monocomponent drug (INN: Mirtazapine, filmcoated 30 Belupo, Drugs Cosmetics d.d., Republic Croatia) Sirdalud MR Tizanidine, modified-release capsules, Novartis Pharm...
here, we report analysis of in vitro and in vivo drug release from an in situ formulation consisting of triamcinolone acetonide (tr) and poly(d,l-lactide-co-glycolide) (plga) and the additives glycofurol and hydroxyapatite nanoparticles (ha). we found that these additives enhanced drug release rate. we used the taguchi method to predict optimum formulation variables to minimise the initial burs...
The objective of the study was to compare pharmacokinetic and pharmacodynamic parameters of gliclazide after administration of immediate (IR) and modified release (MR) tablets. The experiment included rats with both normoglyceamia and streptozocin (STZ)-induced hyperglyceamia. Several MR formulations were designed and in vitro drug release profile was assessed by a dissolution test. For the fur...
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