Estrogen regulates morphological changes in reproductive organs, such as the vagina and uterus, during the estrous cycles in mice. Estrogen depletion by ovariectomy in adults results in atrophy accompanied by apoptosis in vaginal and uterine cells, while estrogen treatment following ovariectomy elicits cell proliferation in both organs. Sequential changes in mRNA expression of wingless-related ...

It is often said that the only constant is change itself. As time passes, the population grows, new technologies are invented, and the skills, demographics, and norms of the populace evolve. These changes, whether in isolation or in aggregate, impact the effectiveness of policy. In particular, policies designed for today’s world are unlikely to provide a perfect fit tomorrow. In this paper we d...

In 2008, California voters went to the polls and passed Proposition 11, which established the California Redistricting Commission. Former Governor Arnold Schwarzenegger strongly urged the passage of this ballot measure as a way to make elections more competitive. The initiative’s drafters sought to solve the legislature’s political stalemate by attacking the legislative system at one of its ear...

Vertebrate somitogenesis comprises the generation of a temporal periodicity, the establishment of anteroposterior compartment identity, and the translation of the temporal periodicity into the metameric pattern of somites. Molecular players at each of these steps are beginning to be identified. Especially, members of the Notch signaling cascade appear to be involved in setting up the somitogene...

AIMS Notch and activin receptor-like kinase 1 (ALK1) have been implicated in arterial specification, angiogenic tip/stalk cell differentiation, and development of arteriovenous malformations (AVMs), and ALK1 can cooperate with Notch to up-regulate expression of Notch target genes in cultured endothelial cells. These findings suggest that Notch and ALK1 might collaboratively program arterial ide...

Neuronal differentiation is regulated by many basic-helix-loop-helix (bHLH) family transcriptional activators and repressors, and the balance of activity between these factors is important for the differentiation process. Here, we report the identification of a novel transcriptional repressor, designated Helt. Helt encoded a Hey-related bHLH protein containing the bHLH and Orange domains. Helt ...