Mg(II), Ca(II) and Ba(II) metal chelates with formulas, [Mg(HL)2(Cl)2].6H2O, [Ca(HL)2(Cl)2].2H2O and [Ba(HL)2(H2O)2].Cl2.2H2O thatHL is the Schiff base moiety formed from condensation of 2-thiophenecarboxaldehyde with 2-chlorophenyl hydrazine have been prepared and characterized by elemental analysis and spectroscopic measurements (infrared and 1 H-NMR). Elemental analysis of the complexes sugg...

Physically crosslinked hydrogels resulted from interaction between N,N,N-trimethyl chitosan chloride (N-Quaternized Chitosan) (NQC) and poly(acrylic acid) (PAA) were synthesized in different weight ratios (3:1), (1:1) and (1:3) taking the following codes Q3P1, Q1P1 and Q1P3, respectively. Characterization of the mentioned hydrogels was done using several analysis tools including; FTIR, XRD, SEM...

Purpose: To study the phytochemical composition of Siphonochalina siphonella sponge from the western coast of the Red Sea and to evaluate the isolates for possible in vitro cytotoxic, antibacterial and antiviral activities. Methods: The compounds obtained were isolated and purified by different chromatographic means. Their structures were established by means of spectral analysis including 1D H...

Two new secondary metabolites, endomeketals A-B (1-2), a new natural product (3), and a known compound (4) were isolated from the ethyl acetate extract of the endophytic fungus Endomelanconiopsis endophytica A326 derived from Ficus hirta. Their structures were determined on the basis of extensive spectroscopic analysis. All compounds were evaluated for their cytotoxic activities against SF-268,...

a series of fluoroquinolone derivatives holding triazolidindione moieties have been synthesized and proved to be cytotoxic agents in vitro particularly against cancer cell lines (sknmc, mcf7, a2780-cp, sw48, a549, kb, ht-29, hepg 2 ). the cytotoxic activity was assessed using mtt colorimetric assay. our compounds had less cytotoxicity than doxorubicin in all studied cell lines.

conclusions considering the strong historical background about the therapeutic potential of the genus hypericum and the considerable cytotoxic and apoptosis induction ability of hypericum scabrum, this species is suggested for future biological studies. results di-chloromethane fraction demonstrated ic50 values of 25.72 μg/ml and 24.73 μg/ml against ht-29 and hepg-2 cell lines, respectively and...

Glibenclamide (Gli) is a widely employed drug in the treatment of type 2 diabetes and many lines of evidence have described its anti-tumor effects in some neoplasms. The aim of the present study was to investigate the effect of Gli on apoptosis of human hepatocellular carcinoma (HCC) cells and to analyze the underlying pathway involved in this action. Two HCC cell lines, HepG-2 and Huh7 were us...