The alcoholic extract of stem of E. pursaetha (PSE, 30, 100, 300 mg/kg body weight, po for 7 days) showed hepatoprotective activity against CCl4 (2 mL/kg body weight, ip)-induced hepatotoxicity. The extract exhibited a significant dose-dependent hepatoprotective effect comparable to standard drug silymarin, by preventing increase in serum levels of alanine aminotransferase, aspartate aminotrans...

Herbal medicines have traditionally been used worldwide for the prevention and treatment of liver disease with fewer adverse effects. The leaves of the Syzygium jambos (SJL) plant were chosen and studied for their antioxidant activity in vitro and hepatoprotective activity in vivo. The antioxidant activity of the ethanol extract was examined in vitro using a 1,1-diphenyl-2-picrylhydrazyl (DPPH)...

AIM To evaluate the hepatoprotective activity of a hydroalcoholic extract of the bark of Anogeissus latifolia; in vitro in primary rat hepatocyte monolayer culture and in vivo in the liver of Wistar rats intoxicated by carbon tetrachloride (CCl(4)). METHODS In the in vitro study, a primary hepatocyte monolayer culture was treated with CCl(4) and extract of Anogeissus latifolia. Hepatoprotecti...

Traditional herbal drugs have a great demand in under developed countries due to their efficacy, low cost and lesser adverse effects, and they are considered to be “natural. Aloe vera at the dose of 500 mg body weight per oral was studied for the gross toxicities and hepatoprotective effect and observed the level of liver biochemical parameters in rabbits. Aloe vera showed highly significant (p...

Hepatoprotective activity of the chloroform extract of the shade dried aerial parts of Solanum trilobatum Linn. was studied in wister rats using the CCl4 induced hepatotoxicity. The activity was evaluated by using biochemical parameters such as serum aspartate amino transferase (AST), alanine amino transferase (ALT), alkaline phosphatase (ALP), total bilirubin and gamma glutamate transpeptidase...

OBJECTIVE Recent studies show that free radicals are important mediators of hepatic injury induced by carbon tetrachloride. Allium (A.) paradoxum showed antioxidant and antihemolytic activities. This work was conduct to determine the possible protective effect of this plant against hepatotoxicity. MATERIALS AND METHODS Subcutaneous injection of 3 ml/kg carbon tetrachloride diluted in olive oi...

BACKGROUND Fulminant hepatic failure (FHF) is clinical syndrome with very poor prognosis and high mortality there is urgent need for the development of safe and non-toxic hepatoprotective agents for the adequate management of hepatitis. Hepatoprotective effect of the Lepidium sativum ethanolic extract (LSEE) was assessed by D-galactosamine-induced/lipopolysaccharide (400 mg/kg and 30 μg/kg) liv...

Hepatoprotective activity of the ethanolic extract of the shade dried aerial parts of Portulaca quadrifida Linn. was studied in wister rats using the CCl4 induced hepatotoxicity. The activity was evaluated by using biochemical parameters such as serum aspartate amino transferase (AST), alanine amino transferase (ALT), alkaline phosphatase (ALP), total bilirubin and gamma glutamate transpeptidas...

The Hepatoprotective and antioxidant activity of pet ether, methanol and aqueous extracts of aerial parts (except fruites) of Cicer arietinum L against ccl4 induced hepatotoxicity in rats. The phytochemical investigations of these extracts showed presence of carbohydrates, proteins, phenols and flavanoids. LD50 values of all extracts were determined. The extracts did not produce any mortality e...

The hepatoprotective activity of red grape seed extracts (GSEs) was investigated against ethanol-induced cytotoxicity. In this study, liver slice culture model was used to demonstrate hepatoprotective activity of two GSEs (water and ethanol) in vitro. The hepatoprotective activity was evaluated by measuring the levels of lipid peroxidation, protein carbonyls, lactate dehydrogenase (LDH) leakage...