Abstract Arsenic trioxide (ATO) is a promising chemotherapeutic agent, but its clinical application limited due to poor pharmacokinetics and dose-limited toxicity. Moreover, the combination of ATO sec-o-glucosylhamaudol (SOG) can improve therapeutic effect hepatoma. In this study, PEGylated magnetic nanographene oxide (PEG@MGO) was used as carriers enhance targeting ability drug delivery system...

OBJECTIVES Hypoxia is a common phenomenon in solid tumors, associated with chemotherapy and radiotherapy resistance, recurrence and metastasis. Hyperbaric oxygen (HBO) therapy can increase tissue oxygen pressure and content to prevent the resistance, recurrence and metastasis of cancer. Presently, Sorafenib is a first-line drug, targeted for hepatocellular carcinoma (HCC) but effective in only ...

Aspartate transcarbamylase was partially purified from rat liver, Morris hepatoma 5123-A or D, Hepatoma 7800, and Novikoff hepatoma and was shown to be inhibited by pyrimidine deoxyribonucleosides and deoxyribonucleotides. The pyrimidine ana logs, 5-bromo-2'-deoxyuridine, 5-bromouridine, 5-bromo-2'-deoxycytidine, 5-fluoro2'-deoxyuridine, 5-fluorouridine, 5-fluoro-2'-deoxycytidine, 5-iodo-2'-deo...

BACKGROUND Previous studies showed Scutellaria barbata D. Don extract (SBE) is a potent inhibitor in hepatoma and could improve immune function of hepatoma H22-bearing mice. However, the immunomodulatory function of SBE on the tumor growth of hepatoma remains unclear. This study aimed to investigate the anti-tumor effects of SBE on hepatoma H22-bearing mice and explore the underlying immunomodu...

A rat hepatoma cell line was shown to synthesize heparan sulfate and chondroitin sulfate proteoglycans. Unlike cultured hepatocytes, the hepatoma cells did not deposit these proteoglycans into an extracellular matrix, and most of the newly synthesized heparan sulfate proteoglycans were secreted into the culture medium. Heparan sulfate proteoglycans were also found associated with the cell surfa...

Rapidly proliferating normal and malignant cells had a greater initial rate of amino acid incorporation into mierosomal proteins than did normal cells. The rate of mierosomal protein renewal in Novikoff hepatoma was greater than that of liver cells. The initial rates of amino acid incorporation into hepatoma and liver ribonueleoprotein particles were approximately equal. The soluble fractions o...