A patient with homozygous sickle cell disease presented with sickle crisis complicated by hepatic and pulmonary sequestration and required intensive therapy. During the recovery phrase she developed a rapid rise of haemoglobin concentration, unrelated to blood transfusion, followed by hypertension, congestive cardiac failure and catastrophic intracerebral haemorrhage. This serious haemodynamic ...

PURPOSE The present pilot study was conducted to detect putative cancer stem cell (CSC) from the hepatic portal system and peripheral blood in the colorectal cancer patients and to compare them to healthy donor and diverticulitis patients. METHODS Laboratory study was performed to identify the expression of cell surface markers, epithelial cell adhesion molecule (EpCAM), cytokeratin (CK) 18, ...

objective: understanding gene expression variations by using rna transcript analysis methods during hepatic viral protein interactions with the ifn pathway in hepatic cell lines has recently gained importance. one of the most powerful techniques in gene expression quantification is quantitative real-time rt-pcr. reference genes used as normalizer in this method may be affected across various ex...

Hepatobiliary radionuclide imaging is typically performed to assess the acute or chronic cholecystitis. Occasionally, initial 1 h imaging reveals an obstructive pattern of radiopharmaceutical distribution with non-visualization of the hepatic or extra-hepatic (EH) bile ducts, gallbladder and small intestinal activity. One hundred and thirty five infants under 12 months of age (65 females and 70...

Coinfection with HIV adversely impacts every stage of hepatitis C (HCV) infection. Liver damage in HCV infection results from host antiviral responses rather than direct viral pathogenesis. Despite depressed cellular immunity, coinfected patients show accelerated hepatic fibrosis compared with HCV monoinfected patients. This paradox is poorly understood. T-regulatory (Treg) cells (CD4+ and FOXP...

Background & Aims The outbreak of coronavirus disease 2019 (COVID-19) has been declared a pandemic. Although COVID-19 is caused by infection in the respiratory tract, extrapulmonary manifestations including dysregulation immune system and hepatic injury have observed. Given high prevalence hepatitis B virus (HBV) China, we sought to study impact severe acute syndrome 2 (SARS-CoV-2) HBV coinfect...