In order to determine the efficacy and safety of ancrod, a rapid acting defibrinogenating drug, for patients with heparin-induced thrombocytopenia, 11 consecutive patients who required anticoagulant therapy because of venous thromboembolism and who developed acute heparin-induced thrombocytopenia or had a history of heparin-induced thrombocytopenia were treated with ancrod. Heparin therapy was ...

Background Heparin induced thrombocytopenia type II (HIT type II) is well defined thrombophylic and immunological complication due to heparin therapy, Witch occurs in 1-3% treated patients. In around 50% of the patients with HIT type II have developed serious thrombotic arterial and venous complications. It has a special place in cardiac surgery, regarding standard use of heparin. In patients w...

Collateral circulation is an alternative source of blood supply to the myocardium if this is jeopardized by failure of the original vessel to provide adequate flow. Gradual occlusion, or a high grade stenosis of the coronary arteries, is frequently associated with collateral development in patients with coronary artery disease. Although the existence of collateral circulation in such patients i...

BACKGROUND Unfractionated heparin therapy is care intensive because of dose-response variability, and because of the necessity of constant intravenous infusion and frequent monitoring. We sought to assess the real-world course of transition from heparin to warfarin in hospitalized patients undergoing anticoagulation therapy for acute venous or arterial thrombosis at our medical center. METHOD...

Patients receive blood thinners (anticoagulants) to treat or prevent blood clots. The most commonly used intravenous anticoagulant is heparin. This Cardiology Patient Page focuses on heparin-induced thrombocytopenia (HIT), a complication of heparin therapy. This complication of heparin is often confusing because in HIT, heparin does the opposite of what it is supposed to do: It forms rather tha...

HARDEN, R. M. (1963): A Method for Intravenous Administration of Heparin in Myocardial Infarction, Brit. med. J., ii, 1106. HOAK, J. C., CONNOR, W. E., and WARNER, E. D. (1966): The Antithrombotic Effects of Sodium Heparin and Sodium Warfarin, Arch. intern. Med., 117, 25. MCCLEERY, R. S., and YARBOROUGH, J. A. (1951): A New Tolerance Test as a Guide to Clinical Heparin Therapy, Circulation, 4, ...

Warfarin requirements are lower in the Chinese, but it is not known if this applies to heparin. We investigated the optimal dose for heparin therapy in Chinese patients, and to assess relationship between i.v. heparin dosage and anticoagulation efficacy. One hundred Chinese patients requiring intravenous heparin therapy were given an initial bolus followed by continuous intravenous infusion. Th...

Background- A reactivation of ischemia after the discontinuation of intravenous heparin in acute coronary syndromes has been described. The effect of glycoprotein IIb/IIIa blockade on heparin rebound is unknown. Methods and Results- Patients with acute coronary syndromes who received heparin therapy but not initial revascularization in the Platelet IIb/IIIa in Unstable angina: Receptor Suppress...