Rodent-borne hantaviruses (family Bunyaviridae, genus Hantavirus) cause hantavirus pulmonary syndrome in the Americas and hemorrhagic fever with renal syndrome in Europe and Asia. The viruses are transmitted to humans mainly by inhalation of virus-contaminated aerosols of rodent excreta and secreta. Classic clinical hemorrhagic fever with renal syndrome occurs in five phases: fever, hypotension...

Hemorrhagic fever with renal syndrome (HFRS) is a serious human disease of zoonotic viral origin. A group of different viruses that belong to the family of hemorrhagic fever could represent with HFRS. The basic pathophysiologic feature is virus-induced leaky microcirculation. There is no effective antiviral treatment against them. Because of rapid environmental changes, global warming, and incr...

Simian Hemorrhagic Fever Virus (SHFV) has caused sporadic outbreaks of hemorrhagic fevers in macaques at primate research facilities. SHFV is a BSL-2 pathogen that has not been linked to human disease; as such, investigation of SHFV pathogenesis in non-human primates (NHPs) could serve as a model for hemorrhagic fever viruses such as Ebola, Marburg, and Lassa viruses. Here we describe the patho...

Background: Arenaviruses are a family of rodent-borne viruses that cause several hemorrhagic fevers. These diseases can be devastating and are often lethal. Herein, to aid in the design and development of diagnostics, treatments and vaccines for arenavirus infections, we have developed a database containing protein sequences from the seven pathogenic arenaviruses (Junin, Guanarito, Sabia, Machu...

There are four dengue virus serotypes, based on molecular analysis. Each serotype is divided to several different genotypes, such as there are 5 genotypes in dengue virus serotype 3 (DENV-3), in which genotype II was confirmed to be the main etiology cause the big dengue fever/dengue hemorrhagic fever outbreak in Vietnam 1998. Molecular epidemiological study was carried out on DENV-3, which cau...

background and aims: crimean-congo hemorrhagic fever (cchf) is a fatal viral disease that occurs in approximately 30 countries. it has the most extensive geographic range among the tick-borne viruses that affect human health. cchf viruses have a tripartite rna genome consisting of large (l), medium (m) and small (s) segments. this study was undertaken to determine the genetic relationship of cc...

conclusions our results showed that the study population perceived a high likelihood of cchf risk. improving public knowledge and awareness could result in a more realistic assessment of cchf risk, hence better compliance with taking precaution measures to tackle the disease. results approximately 70% of the respondents reported the cchf risk to be 'high'. factors independently associated with ...

background crimean-congo hemorrhagic fever (cchf) is a tick-borne disease caused by arbovirus which can be transmitted to human by several routes. tick bite and living in a rural area have been the most common factors for inception of cchf in adults and children in studies reported from iran. objectives this study was conducted to detect the disease acquisition routes among children with confir...

southeast of iran is an endemic area for malaria and crimean-congo hemorrhagic fever ( cchf). in 1999, we faced with an outbreak of cchf in sistan and baluchistan province, in the border of paki­stan and afghanistan. the most cases of malaria in iran are also reported from this area. this arti­cle presents a 17-year- old woman who admitted to our hospital because of acute fever, head­ache, epis...

crimean- congo hemorrhagic fever (cchf) is a viral zoonotic tick-born disease with a mortality rate of up to 50% in humans. after a short incubation period, the disease is characterized by sudden fever, chills, severe headache, dizziness, back, and abdominal pain. additional symptoms can include nausea, vomiting, diarrhea, neuropsychiatric, and cardiovascular changes. in severe cases, hemorrhag...