BACKGROUND The administration of vitamin K immediately after birth has shown a significant decrease in the incidence of newborn bleeding, but there is not enough evidence to determine the most appropriate method of administration. The objective of this review is to determine the effectiveness of orally administered vitamin K compared to the intramuscular route in the prevention of hemorrhagic d...

Hemolytic disease of the newborn due to ABO incompatibility was first observed by Halbrecht in 1944. This entity has a spectrum ranging from minimal hemolysis requiring no therapy, as is the case in most instances, to severe hemolytic disease requiring aggressive management including exchange transfusion in a small percentage of cases. An extreme degree of hemolytic disease of the newborn due t...

This review covers of the results of previously conducted retrospective and prospective clinical trials and data of Cochrane reviews to examine the effects of Dpenicillamine (DPA) for neonatal hyperbilirubinemia and associated low incidence of retinopathy of prematurity (ROP). In the ABOand Rh-Hemolytic Disease of the Newborn (HDN) DPA significantly reduced the need for both initial and repeate...

Red cell alloimmunisation in pregnancy may result haemolytic disease of the foetus and newborn (HDN). During pregnancy, there are possibilities foetal antigen being exposed to mother’s circulation, thereby leading production antibodies. The immunoglobulin G (IgG) antibodies from mother pass through maternal surface placenta, which is then sensitised obstructs formation red blood cells (RBCs). T...

Introduction Routine antenatal serological screening has been practised throughout the United Kingdom and worldwide for about 30 years.' Originally introduced to detect pregnancies at risk of haemolytic disease of the newborn (HDN) due to Rh anti-D antibodies, its continued use has led to an increasing realisation of the clinical importance of other red cell antibodies in the pathogenesis of HD...

By MARY B. COOPER, B.A., M.T. (ASCP) I N 1909, Buchan and Comrie” reported the occurrence of erythrophagocytes in the peripheral blood of 2. newborn infants with ‘ ‘congenital anemia and enlargement of the spleen. ‘ ‘ In 193 I , Abt2 described these cells in blood smears of a case of anemia of the newborn. In 1938, Wyatt, Cooper and Groat9 reported 3 cases of the same disease in which the cells...