Sickle cell disease is the most common inherited hemoglobinopathy associated with adverse maternal and fetal outcomes. It often diagnosed at an early age. Presentation for first time in pregnancy as leucoerythroblastosis rare. Diagnosis requires a strong suspicion demonstration of hemoglobin S blood.

Sickle cell disease is characterized by a very heterogeneous clinical course among patients with the same mutations for sickle hemoglobin (HbS). anemia (SCA) hereditary hemoglobinopathy caused homozygosity of point mutation in beta-globin gene, which leads to substitution glutamic acid valine sixth position.

In Ontario, Canada, beta-thalassemia is easily detected through measurement of hemoglobin A2, but most laboratories do not do exhaustive DNA investigations for alpha-thalassemia. Therefore, the prevalence of thalassemia in microcytic samples for hemoglobinopathy investigation in Ontario is unknown. To address this, we performed a prospective cohort study in which samples referred for hemoglobin...

The purpose of this study was to research the problem of hemoglobin H (HbH) disease, to reveal the distribution patterns among different health centers, and to emphasize the importance of this disease for Turkey. A total of 273 patients were included from 8 hemoglobinopathy centers. The Antakya Hemoglobinopathy Center reported 232 patients and the remaining 7 centers reported 41 patients. PubMe...

V a t a m f e a c a D H s o min Zoraï1 alem Abbes1 1 Laboratory of molecular and cellular ematology, asteur Institute of Tunis, unis El-Manar University, unisia [email protected]> 2 Laboratory of medical biology, ospital A.Mami. Ariana, unisia 3 Service B of pneumology, ospital A.Mami. Ariana, revealed a compound heterozygote, HbO-Arab/cd 39 ◦-thalassemia. This hemoglobinopathy was nev...