hemoglobinopathies are the most common single gene disorders worldwide with a considerable frequency in certain area particularly mediterranean and middle eastern countries. hemoglobinopathies include structural variants of hemoglobin (hb s, hb c, hbe,…) and thalassaemias which are inherited defects in the globin chains synthesis. the present study was conducted to determine the prevalence of h...

In chronic kidney disease (CKD), decreased erythropoietin production, low serum active vitamin D levels, and high renin-angiotensin-aldosterone activities had been regarded as major causes of renal anemia. At present, no clinical data are available to elucidate the association between renal anemia and fibroblast growth factor 23 (FGF23) levels in CKD. This study aimed to access whether FGF23 is...

Evaluation of Serum Levels Vitamin D, Ferritin, and Hemoglobin in Suicide Attempters Admitted or Outpatients Referred to Hospitals Psychiatric Clinics Rafsanjan University Medical Sciences

Hb D-Ouled Rabah [beta19(B1)Asn>Lys] is a rare hemoglobin (Hb) beta chain variant reported from Tuareg tribes in Algeria and once from China. It was suggested that Hb D-Ouled Rabah might be specific of Berber-speaking populations. Our report describes the first observation of this hemoglobin variant in the Turkish population.

Hemoglobin D a hemoglobin variant occurs in a group of asianpopulation particularly from india, Pakistan, Iran, Iraq. In india, it is mainly reported in north western states of Haryana, PunJab and Gujarat. In heterozygous form, Hb D disease is mild and causes subclinical jaundice. In heterozygous form, it can cause severe hemolytic anemia. Here we present a similar case of Hb D with hemolytic j...

Hydroxyurea, a widely used cytotoxic/cytostatic agent that does not influence methylation of DNA bases, increases fetal hemoglobin production in anemic monkeys. To determine its effect in sickle cell anemia, we treated two patients with a total of four, 5-d courses (50 mg/kg per d, divided into three oral doses). With each course, fetal reticulocytes increased within 48-72 h, peaked in 7-11 d, ...

I N T R O D U C T I O N Gary-Bobo and Solomon (1) have proposed that the anomalous osmotic behavior of the erythrocyte is due to a decrease of the net charge of hemoglobin which occurs when the hemoglobin concentration inside the erythrocyte is raised. Employing Donnan equilibrium studies, they subsequently (2) produced evidence to show that a hemoglobin charge dependence on hemoglobin concentr...

Background: Screening and counselling is the most effective way to prevent the birth of children with thalassemia major. An accurate and relatively less time-consuming protocol is necessary to screen large populations. Separating iron deficiency anaemia from thalassemia trait based on blood cell parameters has been used by hematologists for many years. We aimed to design a new approach to scree...

Covid-19 is an infectious disease caused by SARS-CoV 2 and has spread very quickly. Several laboratory examinations were carried out on patients including molecular examinations, hematological profiles, serology. This study aims to determine the relationship between leucocyte, d-dimer, hemoglobin thrombocyte against procalcitonin in with Covid-19. was observational analytic cross sectional desi...

A brief survey of abnormal hemoglobin variants among the major ethnic groups of Karachi was conducted; 202,600 subjects were studied. Patients with low hemoglobin (Hb), low mean cell volume (MCV) and mean cell hemoglobin (MCH) including anemia, microcytosis, hypochromic hemolysis and target cells, were refered for the identification of hemoglobinopathy by molecular methods. Population screening...