Background: Computational modeling of physiology has become a routine element in the development, evaluation, and safety testing many types medical devices. Members Food Drug Administration have recently published manuscript detailing validation, sensitivity computational model for blood volume, cardiac stroke pressure, noting that such might be useful development closed-loop fluid administrati...

Functional near-infrared spectroscopy (fNIRS) can non-invasively measure hemodynamic responses in the cerebral cortex with a portable apparatus. However, the observation signal in fNIRS measurements is contaminated by the artifact signal from the hemodynamic response in the scalp. In this paper, we propose a method to separate the signals from the cortex and the scalp by estimating both hemodyn...

OBJECTIVE Spa therapy is commonly used in the treatment of daily chronic diseases practice, but its benefits are still the subjects of discussion. This study investigates possible effects of a combined spa and physical therapy program on pain and hemodynamic responses in various chronic diseases. METHODS The pain intensity and hemodynamic responses of 472 patients involved in a spa and physic...

Cerebral hemodynamic responses to brief periods of neural activity are delayed and dispersed in time. The specific shape of these responses is of some importance to the design and analysis of blood oxygenation level-dependent (BOLD), functional magnetic resonance imaging (fMRI) experiments. Using fMRI scanning, we examine here the characteristics and variability of hemodynamic responses from th...

OBJECTIVES We sought to determine whether there are age-related differences in vasovagal syncope. BACKGROUND In those with suspected vasovagal (neurocardiogenic) syncope, tilt testing demonstrates different hemodynamic responses. These responses may be age related, reflecting differing underlying pathophysiology. METHODS Using a two-stage tilt protocol with glyceryl trinitrate (GTN) provoca...

Brain imaging techniques utilize hemodynamic changes that accompany brain activation. However, stimulus-evoked hemodynamic responses display considerable inter-trial variability and the sources of this variability are poorly understood. One of the sources of this response variation could be ongoing spontaneous hemodynamic fluctuations. We recently investigated this issue by measuring cortical h...