Cardiac glycosides have been used to treat heart diseases for centuries. Recently, the emerging role of these compounds in cancer treatment is being noticed. Mounting evidences suggest that these steroid-like compounds have both anti-proliferation and pro-apoptosis effects on different human solid tumor cells. Our study mainly focuses on hematological malignant diseases. We took 19 different ki...

Delayed diagnosis of hematological malignancies in immunocompetent patients with fever of unknown origin (FUO) remains an exhausting challenge for non-hematologist physicians. This retrospective cohort study aimed to establish a scoring system, "bone marrow (BM) score", to identify FUO patients who require early bone marrow biopsy (BMB) to diagnose hematological disease. Two cohorts, comprising...

BACKGROUND Complementary and alternative medicine includes a diverse group of medical and healthcare systems, practices and products not considered part of conventional medicine. Although there is information on unconventional practices in oncological diseases, specific data regarding the use of complementary and alternative medicine by hematology patients is scarce. OBJECTIVE The aim of this...

PURPOSE Natural history and consequences of the novel 2009 influenza A H1N1 (2009 H1N1) infection in immunocompromised pediatric patients are not yet fully understood. In this study, we investigated the clinical features and outcomes of the 2009 H1N1 infection in pediatric patients with hematological and oncological diseases. METHODS We retrospectively reviewed the medical records of 528 pati...

Helicobacter pylori infects more than 50% of the world population and is acquired in infan‐ cy. Higher prevalence is found in developing countries, and within geographic areas the predominance correlates inversely with socioeconomic status, especially with living con‐ ditions during childhood. Initially, in adults, H. pylori was only associated with gastric diseases, such as peptic ulcer, gastr...

Pulmonary hypertension (PH), a serious disorder with a high morbidity and mortality rate, is known to occur in a number of unrelated systemic diseases. Several hematological disorders such as sickle cell disease, thalassemia and myeloproliferative diseases develop PH which worsens the prognosis. Associated oxidant injury and vascular inflammation cause endothelial damage and dysfunction. Pulmon...