نتایج جستجو برای: hek 293t
تعداد نتایج: 4682 فیلتر نتایج به سال:
Akt is involved in the regulation of diverse cellular functions such as cell proliferation, energy metabolism, and apoptosis. Although three Akt isoforms are known, the function of each isoform is poorly understood. To gain a better understanding of each Akt isoform, we examined the subcellular localization and expression of each isoform in transformed and nontransformed cells. Akt1 was localiz...
Hierarchical structured nanomaterials with diverse functionality, such as magnetic susceptibility, stimuli-responsiveness, environmental sensing and biocompatibility, are highly sought after for biomedicine and biodetection alike. In this study, we designed and fabricated a new kind of multifunctional core/shell nanospheres as biodegradable targeted drug carriers, the controlled drug release pr...
The vacuolar H(+)-ATPase (V-ATPase) is a major contributor to luminal acidification in epithelia of Wolffian duct origin. In both kidney-intercalated cells and epididymal clear cells, cAMP induces V-ATPase apical membrane accumulation, which is linked to proton secretion. We have shown previously that the A subunit in the cytoplasmic V(1) sector of the V-ATPase is phosphorylated by protein kina...
On the basis of transfection experiments using a dominant-negative approach, our previous studies suggested that PKB (protein kinase B) was not involved in heart PFK-2 (6-phosphofructo2-kinase) activation by insulin. Therefore we first tested whether SGK3 (serum- and glucocorticoid-induced protein kinase 3) might be involved in this effect. Treatment of recombinant heart PFK-2 with [γ-32P]ATP a...
هدف: هدف از این مطالعه بررسی تاثیر DJ-1 بر افزایش بقای سلولهای دوپامین ساز در برابر سمیت پارکینسونی میباشد. مواد و روشها: ابتدا لنتی ویروسهای نوترکیب ناقل توام ژن های DJ-1 و گزارشگر Jred تولید شده و برای آلوده سازی سلولها استفاده شدند. بدین منظور سه پلاسمید لنتی ویروسی بهنامهای ناقل، بسته بندی و غشا برای ترانسفکشن سلولهای HEK-293T بهعنوان رده سلولی...
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