In one corner of the game World of Warcraft, forty players have just gathered in Molten Core to begin their weekly raid. Every Friday night, these players spend five to ten hours working together to defeat the same series of increasingly difficult monsters. Tonight, a sixty-­year-­old female player is raiding with her granddaughter on her lap and the baby’s gurgles are heard over the VoIP chan-...

Background: Elzovantinib is a novel, type I tyrosine kinase inhibitor (TKI) that targets MET, SRC, and CSF1R. Genetic alterations in including exon 14 skipping (Δex14) mutations other oncogenic mutations, amplifications, fusions are present many tumor types. The Phase 1 SHIELD-1 trial (NCT03993873) evaluating safety, pharmacokinetics (PK), preliminary activity of elzovantinib patients (pts) wit...

The ten stories that comprise Losing a Bit of Eden sustain Levi Peterson's position as one the most adept scribes twentieth-century American West. Each story is well grounded in particular time and against specific landscape, somehow all feels gently connected.There no doubt Peterson master language. This volume brimming with striking turns phrase linger long after closes its pages. Several tim...

Background: MET amplifications (METamp) occur in 1–6% of patients (pts) with NSCLC and are associated a poor prognosis. Capmatinib is highly selective potent inhibitor (METi) antitumor activity pretreated treatment-naive pts MET-amplified (gene copy number [GCN] 310) NSCLC. Focal METamp relatively high GCN may be predictor benefit from METi. In this retrospective analysis GEOMETRY mono-1 (NCT02...

Do the operating characteristics of memory continue to bear the imprints of ancestral selection pressures? Previous work in our laboratory has shown that human memory may be specially tuned to retain information processed in terms of its survival relevance. A few seconds of survival processing in an incidental learning context can produce recall levels greater than most, if not all, known encod...

This work is a representation of wave time-series data used in the Maxwave project, with sample time series and statistics of wave height, crest height, trough depth. Data are included from the Ekofisk and Draupner oil fields, and from Belgian coastal waters. In addition, extreme value analysis, and also studies of corrected and evolved time series was performed. INTRODUCTION This report is pre...

introduction prediction of thunderstorm is one of the most difficult issues in weather forecasting. deep convective clouds develop at small spatial and temporal dimensions about 1-10 km and 1-12 h. various thermodynamic parameters have been discovered over the past 40 years, according to data obtained by radiosounds. the capability of these indices in forecasting instability varies over time an...

The medieval eschatological tradition of the ‘15 Signs of the Last Days’ pays special attention to the anguish of animals. This attention seems unnecessary, as animals will not be judged, or resurrected, but only destroyed. Their unnecessary cries might be heard as the cry of life for itself, now useless to God and humans, and also as a reminder to humans of the richness of the worlded selves t...

•MET overexpression provokes targeted therapy resistance in NSCLC•Tissue biopsies surpass liquid ones detecting MET-mediated resistance•MET overexpression, a potential driver, warrants deeper study•MET or SHP2 inhibitors can effectively tackle This study evaluates the efficacy of combining therapies with MET to overcome different NSCLC subtypes. A prevalence was conducted for amplification and ...

•Co-poor Ni-rich layered cathodes (NCM88) for LMBs•Application of a highly stable ILE in LMBs•Long-term performance high-energy positive-electrode material ILE•Performance Li|NCM88|ILE cells employing thin Li electrode High-energy batteries, particular lithium are the key to achieve carbon-neutral mobility. Current lithium-ion batteries have already enabled fast-growing electric vehicles market...