PURPOSE Radiation therapy plays an essential role in the treatment of locally advanced lung cancer, but it inevitably leads to incidental and unnecessary dose to critical organs, including the lung, heart, and esophagus. Numerous radiation dose-volumetric parameters have been associated with increased risk of morbidity and mortality. The purpose of the present study is to quantify differences i...

Introduction: Breast cancer is the most common cancer among women. Radiotherapy plays an important role in the treatment of breast cancer and essential part of the standard treatment after breast-conserving surgery, routinely done to eliminate the microscopic residual cancer. The heart and lungs are one of the most important organs at risk of breast cancer radiotherapy that th...

Optimal dose distribution in the treatment planning system (TPS) is crucial before being applied to radiotherapy patients. However, TPS still uses optimization methods that are time-consuming and user-dependent. This study aimed evaluate automatic prediction model, support vector regression (SVR), compare it with clinically planned of lung cancer Sixty patients treated intensity-modulated radia...

Electronic tissue compensation (eComp) is an external beam planning technique allowing user to manually generate dynamic beam fluence to produce more uniform or modulated dose distribution. In this study, we compared the effectiveness between conventional three-dimensional conformal radiotherapy (3DCRT) and eComp for whole breast irradiation. 3DCRT and eComp planning techniques were used to gen...

Purpose: To compare the dose distribution of three-dimensional conformal radiation therapy (3DCRT) with intensity-modulated (IMRT) for post-mastectomy radiotherapy (PMRT) to left chest wall. Materials and Methods: 30 post-MRM female breast cancer patients histologically confirmed infiltrating ductal carcinoma unilateral without evidence distant metastasis or second malignancy were found eligibl...

Introduction: Breast cancer is the most common cancer among women. Radiotherapy plays an important role in the treatment of breast cancer and essential part of the standard treatment after breast-conserving surgery, routinely done to eliminate the microscopic residual cancer. The heart and lungs are one of the most important organs at risk of breast cancer radiotherapy that th...

PURPOSE To evaluate the feasibility of using helical tomotherapy for locally advanced left-sided breast cancer. METHODS AND MATERIALS Treatment plans were generated for 10 left-sided breast cancer patients with positive lymph nodes comparing a multiport breast (three-dimensional) technique with the tomotherapy treatment planning system. The planning target volumes, including the chest wall/br...

Background: Accurate dose calculations in small beamlets and lung material have been a great challenge for most of treatment planning systems (TPS).  In the current study, the dose calculation accuracy of TiGRT TPS was evaluated for small beamlets in water and lung phantom by comparison to Monte Carlo (MC) calculations. Materials and Methods: The head of Siemens Oncor-impression linac...

Introduction: Internal exposure to radon gas progeny can lead to serious biologic damages to the lung tissue. The aim of this study was to evaluate the absorbed dose by lung tissue due to the exposure from short-lived radioactive products of radon (222Rn) decay using Monte Carlo simulation. Material and Methods: A lung equivalent p...

Objective(s): Due to wide range of medical applications as bactericidal agents, nanosilver particles (NSPs) are manufactured worldwide in large quantities. However, potential toxicity impacts of NSPs in humans and animals still remain poorly understood. The objective of this study was to investigate clinical observations, mortality and pathological changes in rats follow...