Purpose: To compare the dose distribution of three-dimensional conformal radiation therapy (3DCRT) with intensity-modulated (IMRT) for post-mastectomy radiotherapy (PMRT) to left chest wall. Materials and Methods: 30 post-MRM female breast cancer patients histologically confirmed infiltrating ductal carcinoma unilateral without evidence distant metastasis or second malignancy were found eligibl...

The literature is reviewed to identify the main clinical and dose-volume predictors for acute and late radiation-induced heart disease. A clear quantitative dose and/or volume dependence for most cardiac toxicity has not yet been shown, primarily because of the scarcity of the data. Several clinical factors, such as age, comorbidities and doxorubicin use, appear to increase the risk of injury. ...

Editorial Ace inhibitors in heart failure. What dose? The role of ACE (angiotensin converting enzyme) inhibitors in the treatment of heart failure is now well established. A large body of published work has demonstrated relief of symptoms, increased exercise performance, a reduction in hospital admissions and superiority to conventional vasodilators. Three large survival studies (CONSENSUS-1,' ...

In a treatment planning study, radiosurgical treatment plans designed to produce lesions on the left atrium were created using two different methodologies. In one, structures in the heart (mitral valve and coronary arteries) were designated as critical structures while this was not done in the second plan. The treatment plans that were created were compared with standards for heart dose used wh...

introduction: the complex geometry of breast and also lung and heart inhomogeneities near the planning target volume (ptv) result in perturbations in dose distribution. this problem can result in overdosage or underdosage in the match region of the three treatment fields. the purpose of this study is to create a homogeneous dose distribution in the match region between the supraclavicular and t...

in this study, it was surveyed to know whether an oral single dose of oleuropein could mimic the cardiac preconditioning in rats’ hearts or whether its prolonged oral administration could protect the heart against the aconitine-induced arrhythmia in rats. eighty male wistar rats were divided into two series (n = 8 in each group). in the first series, all groups (except the control (con) group) ...

Introduction: Breast cancer is the most common cancer among women. Radiotherapy plays an important role in the treatment of breast cancer and essential part of the standard treatment after breast-conserving surgery, routinely done to eliminate the microscopic residual cancer. The heart and lungs are one of the most important organs at risk of breast cancer radiotherapy that th...