background : a multidimensional approach to health which addresses the psychological features of health justifies the necessity of designing or validation of brief instruments for screening in general population. this study aims to evaluate the reliability and validity of the persian version of the who-5-p as a brief scale of well-being. methods : in this study 451 individuals, i.e., over-15-ye...

OBJECTIVES To evaluate the 12-month costs and quality-adjusted life years (QALYs) gained to the Italian National Health Service of facilitated access to a website for hazardous drinkers compared with a standard face-to-face brief intervention (BI). DESIGN Randomised 1:1 non-inferiority trial. SETTING Practices of 58 general practitioners (GPs) in Italy. PARTICIPANTS Of 9080 patients (>18 ...

Electroconvulsive therapy (ECT) is effective in treatment-resistant depression (TRD). It may act through intracellular process modulation, but its exact mechanism is still unknown. Animal research supports a neurotrophic effect for ECT. We aimed to investigate the association between changes in serum brain-derived neurotrophic factor (sBDNF) levels and clinical improvement following ECT in pati...

The authors report the results of a confirmatory factor analysis of symptoms assessed with the Brief Psychiatric Rating Scale (BPRS) in a sample of 474 patients with schizophrenia, replicated in an independent sample of 327 patients. The most commonly used 5-factor solution for the BPRS fit the data poorly. Exploratory factor analyses performed on the first sample led to the specification of a ...

Factor analytic work on the Positive and Negative Syndrome Scale (PANSS) and Brief Psychiatric Rating Scale (BPRS) has yielded varied and conflicting results. The current study explored potential causes of these discrepancies. Prior research has been limited by small sample sizes and an incorrect assumption that the items are normally distributed when in practice responses are highly skewed ord...

Background: Electroconvulsive therapy (ECT) has been reported being a safe and effective treatment in schizophrenia. However, there are a limited number of studies assessing continuation ECT utilization in patients with schizophrenia giving partial response to pharmacological treatment. Objective: The aim of this study is to evaluate the effectiveness of continuation ECT in preventing relapse i...