Abstract Funding Acknowledgements Type of funding sources: None. Background Non-invasive evaluation left ventricular hemodynamic forces (HDFs) by Cardiac Magnetic Resonance (CMR) is a promising tool to improve systolic and diastolic evaluation. No data are available on athletic population. Purpose To provide the range normal values HDFs in Olympic athletes evaluate possible influence different ...

Human diploid fibroblasts (HDFs) undergo a limited number of cell divisions in culture. After certain population doublings, they reach a state of irreversible growth arrest known as replicative senescence. Senescent HDFs showed several molecular and cytological changes such as large flat morphology, expression of senescence-associated -galactosidase (SA -gal) activity and altered gene express...

Aging and age-related diseases are associated with cellular senescence that results in variable apoptosis susceptibility to oxidative stress. Although fibroblast senescence has been associated with apoptosis resistance, mechanisms for this have not been well defined. In this report, we studied epigenetic mechanisms involving histone modifications that confer apoptosis resistance to senescent hu...

The signaling pathway of insulin/insulin-like growth factor/phosphatidylinositol-3 kinase/Akt/forkhead transcription factors is known to control life span and senescence in organisms ranging from yeast to mice. The FOXO family of forkhead transcription factors, FOXO1, FOXO3a, and FOXO4, play a critical role in this signal transduction pathway. However, the impact of FOXO3a activation on life sp...

In this study, the effects of Chlorella vulgaris (CV) on replicative senescence of human diploid fibroblasts (HDFs) were investigated. Hot water extract of CV was used to treat HDFs at passages 6, 15, and 30 which represent young, presenescence, and senescence ages, respectively. The level of DNA damage was determined by comet assay while apoptosis and cell cycle profile were determined using F...

The IFN-inducible IFI16 and AIM2 proteins act as innate immune sensors for cytosolic double-stranded DNA (dsDNA). On sensing dsDNA, the IFI16 protein induces the expression of IFN-b whereas the AIM2 protein forms an inflammasome, which promotes the secretion of IL-1b. Given that the knockdown of IFI16 expression in human diploid fibroblasts (HDF) delays the onset of cellular senescence, we inve...

Now a day’s, Data is exponentially increasing with the advancement in data science. Each and every digital footprint generating enormous amount of data, which further used for processing various tasks to generate important information different end user applications. To handle such there are number technologies available, Hadoop/HDFS one big handling technology. HDFS can easily large files but ...

Over-expression of the fibroblast elastase neprilysin (NPL) plays a pivotal role in impairing three-dimensional architecture dermal elastic fibers, which results loss skin elasticity and subsequent wrinkle formation (WF). The expression level NPL human fibroblasts (HDFs) is closely associated with epithelial-mesenchymal cytokine interactions (EMCI) via IL-1α GM-CSF, both have potential to stimu...

Major element studies of fluid inclusions in fibrous and cloudy diamonds reveal that most inclusions trapped high density fluids (HDFs) with a wide range of composition. The compositions fall along two arrays between three end-members: carbonatitic to hydroussilicic and carbonatitic to hydrous-saline. Recent studies of diamonds from Siberia and Kankan (Navon et al., 2008; Weiss et al., 2008) fu...