Glycogen stored in skeletal muscle is the main fuel for endurance exercise. The present study examined the effects of oral hydroxycitrate (HCA) supplementation on post-meal glycogen synthesis in exercised human skeletal muscle. Eight healthy male volunteers (aged 22·0 (se 0·3) years) completed a 60-min cycling exercise at 70-75 % VO₂max and received HCA or placebo in a crossover design repeated...

Modelling of the interaction between Hot Carrier Aging (HCA) and Positive Bias Temperature Instability (PBTI) has been considered as one of the main challenges in nanoscale CMOS circuit design. Previous works were mainly based on separate HCA and PBTI instead of Interacted HCA-PBTI Degradation (IHPD). The key advance of this work is to develop a methodology that enables accurate modelling of IH...

Carbonic anhydrase activity was found in the ciliary process of fresh human donor eyes, originating from an enzyme antigenically similar to the erythrocyte high-activity isoenzyme HCA C. It was sensitive to inhibition by acetazolamide and resistant to inhibition by halides like HCA C. The enzyme is probably identical with HCA C. Its tissue concentration was one fifth to one tenth of that in the...

BACKGROUND 2'-Hydroxycinnamaldehyde (HCA) exerts antitumor activity against several human cancer cell lines. However, its antitumor activity in oral cancer has not been demonstrated. MATERIALS AND METHODS The antitumor activity of HCA was assessed in oral cancer cell lines and in a rat oral tumor model. RESULTS Cell cycle analysis confirmed that HCA showed anti-proliferative activity via ce...

We present five cases in whom two rare entities were simultaneously found within the liver, i.e. hepatocellular adenomas (HCAs) and granulomas. Coexistence of both entities confuses diagnosis. Our aim is to disclose the association between HCA and hepatic granulomas. Five patients presented with HCA for which they underwent resection. During laparotomy or at pathological examination, granulomas...

A series of N-acylbenzenesulfonamide dihydro-1,3,4-oxadiazole hybrids (EMAC8000a-m) was designed and synthesized with the aim to target tumor associated carbonic anhydrase (hCA) isoforms IX and XII. Most of the compounds were selective inhibitors of the tumor associated hCA XII. Moreover, resolution of EMAC8000d racemic mixture led to the isolation of the levorotatory eutomer exhibiting an incr...

?Weight to go? for questioning these claims, especially as they seem "too good to be true." Hydroxy citric acid (HCA), a modified form of citric acid, is commonly used as a ?fat burner? [2] in many weight loss supplements. It?s derived from the Garcinia cambogia (G. cambogia), a fruit-bearing tree found Asia, Africa, and the Polynesian islands. HCA is believed to inhibit lipogenesis (the metabo...

?Weight to go? for questioning these claims, especially as they seem "too good to be true." Hydroxy citric acid (HCA), a modified form of citric acid, is commonly used as a ?fat burner? [2] in many weight loss supplements. It?s derived from the Garcinia cambogia (G. cambogia), a fruit-bearing tree found Asia, Africa, and the Polynesian islands. HCA is believed to inhibit lipogenesis (the metabo...

Acute respiratory distress syndrome is a devastating disease that causes substantial morbidity and mortality. Mechanical ventilation can worsen lung injury, whereas ventilatory strategies that reduce lung stretch, resulting in a "permissive" hypercapnic acidosis (HCA), improve outcome. HCA directly reduces nonsepsis-induced lung injury in preclinical models and, therefore, has therapeutic poten...

?Weight to go? for questioning these claims, especially as they seem "too good to be true." Hydroxy citric acid (HCA), a modified form of citric acid, is commonly used as a ?fat burner? [2] in many weight loss supplements. It?s derived from the Garcinia cambogia (G. cambogia), a fruit-bearing tree found Asia, Africa, and the Polynesian islands. HCA is believed to inhibit lipogenesis (the metabo...