OBJECTIVE To define the relationship between HbA(1c) and plasma glucose (PG) levels in patients with type 1 diabetes using data from the Diabetes Control and Complications Trial (DCCT). RESEARCH DESIGN AND METHODS The DCCT was a multicenter, randomized clinical trial designed to compare intensive and conventional therapies and their relative effects on the development and progression of diabe...

BACKGROUND Previous studies have shown a single linear relationship between mean plasma glucose (MPG) and hemoglobin A(1c) (HbA(1c)). We examined the relationship in different treatment groups of patients with type 1 diabetes participating in the Diabetes Control and Complications Trial (DCCT). METHODS Seven-point glucose profiles (premeal, postmeal, and bedtime) and HbA(1c) were measured qua...

The ingested nitrates sourced from tap water, food, chemicals and pharmaceuticals areconverted to nitrites in the body surfaces by bacteria and then, the nitrite ions can lead thestructural changing in hemoglobin. In the present work, aggregation of the purified hemoglobinin adult (HbA) and in fetus or newborn (HbF) in the presence of nitrite ions were studied.Hemoglobin aggregation was perform...

BACKGROUND The evidence for an association between insomnia symptoms and blood hemoglobin A(1c) (HbA(1c)) level has been limited and inconclusive. The aim of this study was to assess whether each symptom of initial, middle, and terminal insomnia influences HbA(1c) level in Japanese men. METHODS This cross-sectional study examined 1,022 male workers aged 22-69 years with no history of diabetes...

• Measurement of solvation interactions for deep eutectic solvents (DESs) is discussed. DES power varies with hydrogen bond acceptor (HBA)/hydrogen donor (HBD) ratio. Inverse gas chromatography sensitive to measure small variations in HBA/HBD Eighteen mixtures varied HBA and HBD composition are examined. Hydrogen basicity impacted the most when ratio varied. Deep have gained increasing populari...

We studied whether problems quantifying hemoglobin A(2) (HbA(2)) could be resolved by using capillary electrophoresis. HbA(2) was quantified on whole blood samples from patients with and without beta-thalassemia trait and patients heterozygous for HbE, HbS, HbC, and HbD Punjab using the VARIANT II beta-thalassemia (Bio-Rad, Hercules, CA) and Capillarys 2 (Sebia, Norcross, GA). HbA(2) results in...

OBJECTIVE Current recommendations for the use of hemoglobin A(1c) (HbA(1c)) in diabetes screening and diagnosis aim to identify those at greatest risk for diabetic microvascular complications. However, there is current controversy regarding the clinical implications of ethnic differences in HbA(1c) values. The objective of this study was to determine whether the association between HbA(1c) and ...

OBJECTIVE People with type 1 diabetes have increased risk of hospital admission compared with those without diabetes. We hypothesized that HbA(1c) would be an important indicator of risk of hospital admission. RESEARCH DESIGN AND METHODS The Scottish Care Information-Diabetes Collaboration, a dynamic national register of diagnosed cases of diabetes in Scotland, was linked to national data on ...

OBJECTIVE The Internet is used worldwide as a communication tool. To improve the quality of diabetes control, we investigated the effectiveness of an Internet-based blood glucose monitoring system (IBGMS) on controlling the changes in HbA(1c) levels. RESEARCH DESIGN AND METHODS We conducted a randomized clinical trial involving 110 patients who visited the outpatient clinic at the Kangnam St....

Under anaerobic conditions, structurally diverse aromatic compounds are catabolized by bacteria to form benzoyl-coenzyme A (benzoyl-CoA), the starting compound for a central reductive pathway for aromatic ring degradation. The structural genes required for the conversion of 4-hydroxybenzoate (4-HBA) to benzoyl-CoA by Rhodopseudomonas palustris have been identified. Here we describe a regulatory...