The dystonic rat (dt) is an autosomal recessive mutant displaying a complex motor syndrome that includes sustained axial twisting movements. The syndrome is correlated with increased glutamic acid decarboxylase activity in the deep cerebellar nuclei and increased cerebellar norepinephrine levels in comparison with phenotypically normal littermates. Biochemical, behavioral, and anatomical techni...

Effects of harmaline on excitability of crayfish giant axon in relation to effects on Na,K-ATP activity were investigated and the findings were compared with relative data on ouabain. Exposure of the axon to harmaline in doses over 0.5 mM resulted in a dose-dependent reduction of the action potential. Harmaline of 2.5 mM produced a complete blockade of the action potential with a slight decreas...

Introduction: β-carbolines are shown to have significant anti-inflammatory effect via the inhibition of some inflammatory mediators including TNF-α and PGE2. In previous studies Purkinje cell deterioration have been proposed the dominant pathogenesis of harmaline toxicity. WIN55, 212-2 is a non-selective cannabinoid CB1 and CB2 receptor agonist. Combination of WIN55, 212-2 ...

Introduction: The Cannabinoid receptors (CBR) densities are high within the cerebellum. Cannabinoid receptors manipulations have been reported to cause altering the cerebellar functions. harmaline have immune-modulatory effects in several studies. i.e., significant anti-inflammatory effect via the inhibition of prostaglandin E2 (PGE2) and tumor necrosis factor alpha (TNF-α). Endocannabino...

this study was designed to examine the effects of intracerebroventricular (icv) injection of ketanserin(5-ht2a receptor antagonist) and sb242084 (5-ht2c receptor antagonist) on harmaline induced feeding anddrinking response in 24-h food-deprived (fd24) broiler cockerels. at first, guide cannula was surgicallyimplanted in the right lateral ventricle of chickens. in experiment 1, birds were injec...

introduction: the plethora of studies indicated that there is a cross talk relationship between harmaline and serotonergic (5-ht) system on cognitive and non-cognitive behaviors. thus, the purpose of this study is to assess the effects of hippocampal 5-ht4 receptor on memory acquisition deficit induced by harmaline.  methods: harmaline was injected peritoneally, while 5-ht4 receptor agonist (rs...

Therapeutic potential of harmaline, a novel alkaloid, against cervical cancer cells in vitro: Apoptotic induction and DNA interaction studyParomita Bhattacharjee, Sarita Sarkar, Tapas Ghosh, Kakali Bhadra

Objective(s): Due to unsatisfactory response or intolerable side effects of current drugs, treatment of essential tremor remains inadequate. Thus, we aimed to investigate the protective and therapeutic effects of aqueous and ethanolic extracts of Crocus sativus (saffron), and its active consistent, safranal, on the harmaline-induced tremor in mice. Materials and Methods: To induce tremor, harma...

Salimuzzaman Siddiqui*. Bina S. Siddiqui, and Sabira Begum H. E. J. Research Institute of Chemistry, University of Karachi, Karachi-32, Pakistan Z. Naturforsch. 41b, 1583-1586 (1986); received March 20, 1985/July 20, 1986 Harmaline, Aminoharmaline, Harmalol, N-Benzenesulfonyltetrahydroharmine In the course of pharmaco-chemical studies in the structure and activity relationship in har­ maline se...

BACKGROUND Although essential tremor (ET) is the most common tremor disorder, its pathogenesis is not fully understood. The traditional model of ET, proposed in the early 1970s, posited that the inferior olivary nucleus (ION) was the prime generator of tremor in ET and that ET is a disorder of electrophysiological derangement, much like epilepsy. This article comprehensively reviews the origin ...