Botulism food poisoning is caused primarily by ingestion of the Clostridium botulinum neurotoxin (BoNT). The 1300 amino acid BoNT forms a progenitor toxin (PTX) that, when associated with a number of other proteins, increases its oral toxicity by protecting it from the low pH of the stomach and from intestinal proteases. One of these associated proteins, HA1, has also been suggested to be invol...

A field experiment was conducted at R.G.S.C, Banaras Hindu University, Mirzapur, Uttar Pradesh, India during 2016 in kharif season (Sep.-Oct.) The aim to evaluate the effect of different nitrogen, phosphorus and potassium level on fodder production sudan grass (Sorghum bicolor var. Sudanese) for optimization growth yield, crude protein content economics grass. experimental laid out split plot d...

Membrane extracts from chicken smooth muscle contain, along with filamin, vinculin and alpha actinin, a group of polypeptides that have the ability to interact with the "barbed end" of actin filaments. These low molecular mass polypeptides were designated as HA1 (Wilkins, J.A., and S. Lin, 1986, J. Cell Biol., 102:1085-1092). In this study, polyclonal antibodies raised against the HA1 preparati...

BACKGROUND In the face of impending influenza pandemic, a rapid vaccine production and mass vaccination is the most effective approach to prevent the large scale mortality and morbidity that was associated with the 1918 "Spanish Flu". The traditional process of influenza vaccine production in eggs is time consuming and may not meet the demands of rapid global vaccination required to curtail inf...

The effects of a municipal solid waste compost (MSWC) (from Villarrasa-HuelvaSpain) on growth, yield and mineral composition of tomato plants (Lycopersicon esculentum Miller, cv. Genaro) were studied. Results were compared with those observed both without the application of organic matter (Control) and with the app1ication of a commercial compost AC (made from sheep manure). Soils of the three ...

The HA1 domain of HA, the major antigenic protein of influenza A viruses, contains all of the antigenic sites of HA and is under continual immune-driven selection. To resolve controversies on whether only a few or many residue sites of HA1 have undergone positive selection, whether positive selection at HA1 is continual or punctuated, and whether antigenic change is punctuated, we introduce an ...

Influenza A viruses are a respiratory pathogen that cause annual epidemics as well as many well-known pandemics such as Russian flu (1889), Spanish flu (1918), Asian Flu (1957) and the recent Mexico swine flu (2009). The viral envelope, the hemagglutinin (HA), in particular HA1, confers the antigenic sites, receptor binding sites and induces immune response. HA1 of the H1 influenza consists of ...

The application of microbial products as natural biocontrol agents for inducing systemic resistance against plant viral infections represents a promising strategy sustainable and eco-friendly agricultural applications. Under greenhouse conditions, the efficacy culture filtrate Bacillus subtilis strain HA1 (Acc# OM286889) protecting tomato plants from Tobacco mosaic virus (TMV) infection was ass...

Genetic Recombination in the 1918 “Spanish Flu” Virus Influenza viral sequences have been obtained from preserved tissues of victims of the “Spanish flu” pandemic that killed over 20 million people from 1918 to 1919 (1, 2). Phylogenetic analysis of hemagglutinin (HA) gene sequences has indicated that the 1918 Spanish flu virus was more closely related to the human lineage than to the swine or a...

background: influenza viruses are a significant cause of morbidity and mortality. the influenza virus pandemics, 1918, 1977, and especially the most recent one, a/h1n1/2009, made evident the need for generating recombinant influenza h1n1 antigens which are essential to develop both basic and applied research programs. among influenza virus proteins, haemagglutinin (ha) is a major surface antige...