Crystals of an ion-channel-forming peptaibol peptide in a partial membrane environment have been obtained by cocrystallizing antiamoebin with n-octanol. The antiamoebin molecule has a bent helical conformation very similar to that established for Leu-zervamicin, despite a significantly different sequence for residues 1-8. The bent helices assemble to form a polar channel in the shape of an hour...

Non-O157 Shiga toxin-producing Escherichia coli (STEC) strains are clinically significant food-borne pathogens. However, there is a dearth of information on serotype prevalence and virulence gene distribution, data essential for the development of public health protection monitoring and control activities for the meat and dairy industries. Thus, the objective of this study was to examine the pr...

Segregation for 289 random amplified polymorphic DNA markers (RAPDs) has been determined in 106 F z plants of an interspecific hybrid (H27) between M icro~eris douglasii (strain B14) and M. bigelovii (C94). Multicelluar trichomes ("type D", specific for Microseris) occur on the leaf teeth of early vegetative rosettes of the B 14 parent and on the leaf blades of later rosettes in both parents. T...

Following a large outbreak of foodborne gastrointestinal (GI) disease, a multiplex PCR approach was used retrospectively to investigate faecal specimens from 88 of the 413 reported cases. Gene targets from a range of bacterial GI pathogens were detected, including Salmonella species, Shigella species and Shiga toxin-producing Escherichia coli, with the majority (75%) of faecal specimens being P...

plentifulness of oil resources on the one hand, and serious economic challenges in the course of development of the country, on the other hand, makes the optimum use of these resources a considerable issue in achieving the goals of sustainable development. iran’s experience in establishing exchange reserve account (era) during 2000-2005 indicates that its main function is saving the surplus rev...

The conformational properties of the aminoacyl-tRNA binding site (A-site), and its surroundings in the Escherichia coli 30S ribosomal subunit, are of great relevance in designing antibacterial agents. The 30S subunit A-site is near ribosomal protein S12, which neighbors helices h27 and H69; this latter helix, of the 50S subunit, is a functionally important component of an intersubunit bridge. E...

A series of new 1-[(2, 3-dichloroanilinomalonyl)]-3-(N-2’-cyanoethyl-N-2, 3-dichloroanilino)-5phenyl pyrazoline have been synthesized in 48 to 77% yield, by the reaction of N-cinnamoyl-N-2’cyanoethyl-2, 3-dichloroaniline with Ethyl-2-(2,3-dichloroanilido) acetohydrazide. Pyrazolines are yellow, cream and brown color solids, having high melting points. Identity of these products has been establi...

BACKGROUND In order to control malaria, it is important to understand the genetic structure of the parasites in each endemic area. Plasmodium vivax is widely distributed in the tropical to temperate regions of Asia and South America, but effective strategies for its elimination have yet to be designed. In South Korea, for example, indigenous vivax malaria was eliminated by the late 1970s, but r...