Native buckwheat, a common component of food products and medicine, has been observed to inhibit cancer cell proliferation in vitro. The aim of the present study was to evaluate the in vitro and in vivo anti-tumoral effects of recombinant buckwheat trypsin inhibitor (rBTI) on hepatic cancer cells and the mechanism of apoptosis involved. Apoptosis in the H22 cell line induced by rBTI was identif...

Lotus is an edible and medicinal plant, and the extracts from its different parts exhibit various bioactivities. In the present study, the hot water-soluble polysaccharides from lotus seeds (LSPS) were evaluated for their cancer cell cytotoxicity, immunomodulatory and antitumor activities. LSPS showed significant inhibitory effects on the mouse gastric cancer MFC cells, human liver cancer HuH-7...

OBJECTIVE To prepare hydroxyethyl chitosan nanoparticles loaded with anti-human death receptor 5 single-chain antibody, and study their characteristics, functions, and mechanisms of action. MATERIALS AND METHODS The anti-human death receptor 5 single-chain antibody was constructed and expressed. Protein-loaded hydroxyethyl chitosan nanoparticles were prepared, and their size, morphology, part...

The steady rise in income and wealth inequality the last four decades, together with evolution of a vanishing middle class, has raised concerns about potentially pernicious effects these trends on social stability economic growth. This paper evaluates possibility designing tax systems aimed at reducing bipolarization. Using two fundamentally different metrics, we provide unified foundation prog...

The root of Actinidia valvata dunn has been widely used in the treatment of hepatocellular carcinoma (HCC), proved to be beneficial for a longer and better life in China. In present work, total saponin from root of Actinidia valvata Dunn (TSAVD) was extracted, and its effects on hepatoma H22-based mouse in vivo were observed. Primarily transplanted hypodermal hepatoma H22-based mice were used t...

Let H = ( H11 H12 H∗ 12 H22 ) be an n×n positive semidefinite matrix, where H11 is k×k with 1 ≤ k < n. The generalized Schur complement of H11 in H is defined as S(H) = H22 −H∗ 12H † 11H12, where H 11 is the Moore-Penrose generalized inverse of H11. It has the extremal characterizations S(H) = max { W : H − ( 0k 0 0 W ) ≥ 0,W is (n− k)× (n− k) Hermitian } and S(H) = min {[Z|In−k]H[Z|In−k] : Z i...

We investigated the anti-tumor effects of Verbena officinalis extract on H22 tumor-bearing mice and its effect on immune function. Mice model of H22 solid tumor was established, the mice were divided into five groups and administered the extract, later, tumors were removed and inhibition rates were calculated; spleens were removed and spleen indices were calculated, and the sheep red blood cell...

The propagation of spatio-temporal errors in precipitation estimates to runoff errors in the output from the conceptual hydrological HBV model was investigated. The study region was the Gimån catchment in central Sweden, and the period year 2002. Five precipitation sources were considered: NWP model (H22), weather radar (RAD), precipitation gauges (PTH), and two versions of a mesoscale analysis...

Hepatocellular carcinoma shows low response to most conventional chemotherapies; additionally, extrahepatic metastasis from hepatoma is considered refractory to conventional systemic chemotherapy. Target therapy is a promising strategy for advanced hepatoma; however, targeted accumulation and controlled release of therapeutic agents into the metastatic site is still a great challenge. Folic aci...